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MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS390 | MetaboLights
MetabolomicsA Pilot Characterization of the Human Chronobiome
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors in humans. Here we integrated data ...
2018-05-16 | MTBLS656 | MetaboLights
TranscriptomicsChemical modifications mark alternatively spliced and actively degrading messenger RNAs in Arabidopsis and humans
Post-transcriptional chemical modification of RNA bases is a widespread and physiologically relevant regulator of RNA maturation, stability, and function. While modifications are best characterized in short, noncoding RNAs such as transfer RNAs (tRNAs), growing evidence indicates that messenger RNAs...
ORGANISM(S): Homo sapiens 
2015-10-31 | E-GEOD-66224 | biostudies-arrayexpress
TranscriptomicsExpression data from Fog1+/+ and Fog1 ki/ki mouse megakaryocyte-erythroid progenitors (MEP).
The transcription co-factor FOG1 interacts with the chromatin remodeling complex NuRD to mediate gene activation and gene repression during hematopoiesis. We have generated mice with a targeted mutation in the endogenous Fog1 locus that results in an N-ternimal mutation in FOG1 that disrupts the int...
ORGANISM(S): Mus musculus 
2010-04-11 | E-GEOD-19497 | biostudies-arrayexpress
TranscriptomicsThe structure of human Argonaute-2 in complex with miR-20a
Argonaute proteins lie at the heart of the RNA-Induced Silencing Complex (RISC), wherein they use small RNA guides to recognize targets. Some Argonaute proteins can directly cleave their targets, whereas others recruit co-factors to repress independently of “slicing.” Prior studies established the a...
ORGANISM(S): Spodoptera frugiperda 
2012-05-12 | E-GEOD-37931 | biostudies-arrayexpress
TranscriptomicsMapping Clinical and Expression QTL in a Sex-Dependent Effect of Host Susceptibility to Influenza H3N2/HK/1/68-MA20
Seasonal influenza outbreaks and recurrent influenza pandemics present major challenges to public health. By studying immunological responses to influenza in different host species, it may be possible to discover common mechanisms of susceptibility in response to various influenza strains. This coul...
ORGANISM(S): Mus musculus 
2012-05-01 | E-GEOD-35888 | biostudies-arrayexpress
UnknownElectrical activity at the AlN/Si Interface: identifying the main origin of propagation losses in GaN-on-Si devices at microwave frequencies.
Not available
S-EPMC7447785 | biostudies-literature
UnknownGenotyping of Chlamydophila psittaci by real-time PCR and high-resolution melt analysis.
Not available
S-EPMC2620869 | biostudies-literature
UnknownPrognostic, biological, and structural implications of FLT3-JMD point mutations in acute myeloid leukemia: an analysis of Alliance studies.
Not available
S-EPMC11879849 | biostudies-literature
UnknownAccelarated immune ageing is associated with COVID-19 disease severity.
Not available
S-EPMC10782727 | biostudies-literature
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