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TranscriptomicsProfiling of Islet, Lim3, Hb9 and Eve genomic binding in Drosophila with DamID
While developmental processes such as axon pathfinding and synapse formation have been characterized in detail, comparatively less is known of the intrinsic developmental mechanisms that regulate transcription of ion channel genes in embryonic neurons. Early decisions, including motoneuron axon targ...
ORGANISM(S): Drosophila melanogaster 
2014-02-18 | E-GEOD-53446 | biostudies-arrayexpress
ProteomicsNADPH Gating and F-Actin Engagement Define the Structural Bases of MICAL1 Autoinhibition and Activation
Human MICAL1 belongs to the MICAL multidomain protein family exhibiting an unprecedented [AG3.1]actin depolymerizing activity through the NADPH-dependent oxidoreductase reaction catalyzed by their N-terminal flavoprotein domain. Free MICAL1 exists in an autoinhibited state. Its relief upon interacti...
ORGANISM(S): Homo sapiens (Human) 
2026-10-15 | PXD077485 | Pride
Cryo‐electron microscopy Flavoprotein Enzyme structure Actin Enzyme mechanism Crosslinking mass spectrometry Xl-ms Oxidation-reduction 
ProteomicsG9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered TCR-T cells against hepatocellular carcinoma
Engineered T cells transiently expressing tumor-targeting receptors are an attractive form of engineered T cell therapy as they carry no risk of insertional mutagenesis or long-term adverse side-effects. However, multiple rounds of treatment are often required, increasing patient discomfort and cost...
ORGANISM(S): Homo Sapiens (human) 
2023-01-19 | PXD039542 | JPOST Repository
TranscriptomicsTranscription profiling of human T-ALL cell cultures treated with Compound E, a gamma-secretase inhibitor or vehicle only (DMSO) for 24 h
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T-cell development and in the pathogenesis over 50% of human T-cell lymphoblastic leukemia (T-ALL) cases. However, little is known about the transcrip...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5827 | biostudies-arrayexpress
UnknownA bifunctional kinase-phosphatase module balances mitotic checkpoint strength and microtubule attachment dynamics
Not available
S-SCDT-10_15252-EMBJ_2022112630 | biostudies-other
UnknownHPV8-induced STAT3 activation led keratinocyte stem cell expansion in human actinic keratoses.
Not available
S-EPMC11383611 | biostudies-literature
OtherProteomics of muscle chronological ageing in post-menopausal women.
Data from ProteomeXchange, PXD ID: PXD001527. File: E-PP-proteolyse-682(1179).mgf Published as part of BMC Genomics. 2014 15:1165 . From the Abstract: {{i}} Muscle samples were compared between adult (56 years) and old (78 years) post-menopausal women. In addition to total muscle extracts, low-ioni...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32310006844 | GPMDB
Resource Reanalysis 
UnknownSOX9 maintains human fetal lung tip progenitors by enhancing WNT and RTK signalling
Not available
S-SCDT-EMBOJ-2022-111338 | biostudies-other
UnknownA homozygous MED11 C-terminal variant causes a lethal neurodegenerative disease.
Not available
S-EPMC10519206 | biostudies-literature
UnknownOutcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes: A FIDELITY Subgroup Analysis.
Not available
S-EPMC10278789 | biostudies-literature
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