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TranscriptomicsMicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.
microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas loss of function reverses this phenot...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-14831 | biostudies-arrayexpress
TranscriptomicsmiRNA expression data from MCF-7 cells, overexpressing ANXA1
Annexin 1 (ANXA1), an endogenous anti-inflammatory protein which modulates cellular processes such as proliferation, differentiation and apoptosis has been implicated in cancer initiation and progression. ANXA1 was previously shown to be regulated by hsa-miR-196a and promoted cell proliferation and...
ORGANISM(S): Homo sapiens 
2015-01-05 | E-GEOD-54439 | biostudies-arrayexpress
TranscriptomicsmiR-122 as a Regulator of Mitochondrial Metabolic Gene Network in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues fro...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22058 | biostudies-arrayexpress
UnknownLoss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration.
Not available
S-EPMC4147312 | biostudies-literature
TranscriptomicsmicroRNAs involved in regulating embolic stroke recovery following spontaneous reperfusion [miRNA]
To date, miRNA expression studies on cerebral ischemia in both human and animal models have focused mainly on acute phase of ischemic stroke. In this study, we present the roles played by microRNAs in the spontaneous recovery phases in cerebral ischemia using rodent stroke models. In this study pres...
ORGANISM(S): Rattus norvegicus 
2013-12-09 | E-GEOD-46266 | biostudies-arrayexpress
UnknownMiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells.
Not available
S-EPMC4480726 | biostudies-literature
TranscriptomicsmiRNAs involved in regulating embolic stroke recovery following spontaneous reperfusion
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2013-12-09 | E-GEOD-46269 | biostudies-arrayexpress
TranscriptomicsExpression data from U87-2M1 glioma cells transduced with baculoviral control decoy vector or baculoviral miR-10b decoy vector
MicroRNA-10b may target numerous genes in gliomagenesis. The target genes of miR-10b may differ according to the cellular context. We used microarray analyses to determine the phenotypic effects and gene targets of miR-10b by silencing miR-10b in invasive U87-2M1 glioma cells. Early passage U87-2M1 ...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-35170 | biostudies-arrayexpress
UnknownThe microRNAs miR-200b-3p and miR-429-5p target the LIMK1/CFL1 pathway to inhibit growth and motility of breast cancer cells.
Not available
S-EPMC5689609 | biostudies-literature
UnknownDownregulation of long noncoding RNA breast cancer anti-estrogen resistance 4 inhibits cell proliferation, invasion, and migration in esophageal squamous cell carcinoma by regulating the microRNA-181c-5p/LIM and SH3 protein 1 axis.
Not available
S-EPMC9275979 | biostudies-literature
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