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TranscriptomicsTranscription profiling of mouse E10.5 limb bud ZPA and the rest of the E10.5 limb bud from Shhgfpcre heterozygotes separated by FACS
Comparing gene expression of cells from the E10.5 limb bud ZPA and the rest of the E10.5 limb bud from Shhgfpcre heterozygotes separated by FACS. Experiment Overall Design: 8 samples, 4 ZPA and 4 rest of the limb
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7598 | biostudies-arrayexpress
ProteomicsRoles of Mettl14 in mouse limb bud development
m6A regulates virtually every step in RNA metabolism. However, its toles in limb development remains largely unknown. To understand the roles, we created a limb bud-specific conditional knockout (cKO) mice and control heterozygous (cHet) mice of the Mettl14 gene, which encodes an essential subunit i...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-03 | PXD049092 | Pride
Mettl14 Mouse Limb bud Quantitative mass spectrometry 
TranscriptomicsBhlha9 deficiency effect in limb bud
Analysis of mouse limb bud (E10.5) lacking the Bhlha9 gene. Bhlha9 knockout mouse shows syndactyly and poliosis in the limb. This microarray results provides insight into the molecular mechanisms underlying Bhlha9 function in the limb development DNA microarray analysis was performed using Affymetri...
ORGANISM(S): Mus musculus 
2016-05-31 | E-GEOD-81223 | biostudies-arrayexpress
TranscriptomicsEarly limb bud transcriptome analysis between anterior and posterior domain
Shh signal mediated by Gli family of transcription factors regulates digit growth and patterning in early limb development. Shh expression in the posterior margin of the limb bud defines the zone of polarizing activity. However, much less is know about downstream targets that mediate Shh signal func...
ORGANISM(S): Mus musculus 
2013-01-06 | E-GEOD-41691 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional landscape of human embryonic limb development
Human limbs emerge during the fourth post-conception week as mesenchymal buds, which develop into fully formed limbs over the subsequent months. This process is orchestrated by numerous temporally and spatially restricted gene expression programmes, making congenital alterations in phenotype common....
ORGANISM(S): Homo sapiens 
2022-04-15 | E-MTAB-8813 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of chicken anterior and posterior wing bud thirds from stage HH24 normal and talpid3 mutant embryos
Relative levels of RNA transcripts were compared between anterior and posterior wing bud thirds from stage HH24 normal and talpid3 mutant chicken embryos using chicken Affymetrix chips. Data collected with Affymetrix scanner was normalized using the Plier algorithm within the expression console pack...
ORGANISM(S): Gallus gallus 
2010-08-12 | E-MTAB-309 | biostudies-arrayexpress
TranscriptomicsChromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb.
The regulatory elements that direct tissue-specific gene expression in the developing mammalian embryo remain largely unknown. Although chromatin profiling has proven to be a powerful method for mapping regulatory sequences in cultured cells, chromatin states characteristic of active developmental e...
ORGANISM(S): Mus musculus 
2012-03-16 | E-GEOD-30641 | biostudies-arrayexpress
GenomicsExpression data from Limb bud cells
Expression data from Limb bud cells
PRJNA523825 | ENA
TranscriptomicsRNA sequencing of chicken limb distal mesenchyme cells to compare gene expression over time and in heterochronic grafted cells
Distal limb mesenchyme cells were collected from embryonic chickens at Hamburger Hamilton (HH) stages HH24, HH27, and HH29, and also from samples that had been grafted from HH27 to HH20 and left to develop for 24 hours (equivalent to HH24). Samples were collected in triplicate (with 10 distal tips p...
ORGANISM(S): Gallus gallus 
2018-04-20 | E-MTAB-6437 | biostudies-arrayexpress
TranscriptomicsFUNCTIONAL ANALYSIS OF CTCF DURING MAMMALIAN LIMB DEVELOPMENT_whole transcriptome
Limb buds were dissected from E10.75 mouse embryos and stored in RNAlater reagent (Qiagen), for genotyping. For each replicate, RNA was isolated from pools of 6 limb buds either of wild type or homozygous mutants using RNeasy micro-kit (Qiagen). rRNA was depleted using RiboMinusTM Human/Mouse Transc...
ORGANISM(S): Mus musculus 
2011-11-01 | E-MEXP-2980 | biostudies-arrayexpress
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