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ProteomicsRoles of Mettl14 in mouse limb bud development
m6A regulates virtually every step in RNA metabolism. However, its toles in limb development remains largely unknown. To understand the roles, we created a limb bud-specific conditional knockout (cKO) mice and control heterozygous (cHet) mice of the Mettl14 gene, which encodes an essential subunit i...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-03 | PXD049092 | Pride
Mettl14 Mouse Limb bud Quantitative mass spectrometry 
ProteomicsPrimarily Dissecting the Autonomous and Cooperative Functions of METTL3 and METTL14 in mRNA Modification and Tumor Progression
METTL3 and METTL14 are considered to faithfully form the m6A writing complex in a 1:1 ratio, regulating the fate of mRNA by adding m6A modifications. However, recent studies have shown inconsistent expression and prognostic value of METTL3 and METTL14 in some tumors, suggesting that they may not be ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-01 | PXD048886 | Pride
Mettl3 Independent Splicing Mettl14 Proliferation 
ProteomicsCancer Mutations Rewire the RNA Methylation Specificity of METTL3-METTL14
Chemical modification of RNAs is important for post-transcriptional gene regulation. The METTL3-METTL14 complex generates most N6-methyladenosine (m6A) modifications in mRNAs, and dysregulated methyltransferase expression has been linked to numerous cancers. Here we show that m6A modification locati...
ORGANISM(S): Homo sapiens (Human) 
2024-12-21 | PXD039447 | Pride
Oncogenesis Mettl3 M6a Mettl14 Lc-ms/ms Hepg2 
ProteomicsSpecific sDMA Modifications on the RGG/RG Motif of METTL14 Regulate Its Function in AML
Protein arginine methylations are crucial post-translational modifications (PTMs) in eukaryotes, playing a significant regulatory role in diverse biological processes. Different forms of arginine methylations are known to co-exist within densely modified arginine-rich protein regions. However, pinpo...
ORGANISM(S): Homo Sapiens 
2024-08-05 | PXD054570 |
GenomicsMETTL14 regulates neuroblastoma through the m6A modification
METTL14 regulates neuroblastoma through the m6A modification
PRJNA1022448 | ENA
GenomicsKnockdown of METTL14 inhibits the development of neuroblastoma
Knockdown of METTL14 inhibits the development of neuroblastoma
PRJNA1023971 | ENA
GenomicsChIP-seq of HA-METTL14 in HepG2 cells
ChIP-seq of HA-METTL14 in HepG2 cells
PRJNA499113 | ENA
GenomicsTranscriptome analysis after METTL14 overexpression in ocular melanoma cells
Transcriptome analysis after METTL14 overexpression in ocular melanoma cells
PRJNA888408 | ENA
GenomicsMETTL14 facilitates global genome repair and suppresses skin tumorigenesis
METTL14 facilitates global genome repair and suppresses skin tumorigenesis
PRJNA608744 | ENA
GenomicsPAR-CLIP-seq of HA-METTL14 in HepG2 cells
PAR-CLIP-seq of HA-METTL14 in HepG2 cells
PRJNA499119 | ENA
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