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TranscriptomicsBinding motif analysis of METTL3，WTAP in METTL3，WTAP overexpressed Human 293T cells
label the cells overexpressed Myc tagged METTL3 and Flag tagged WTAP with 4-SU, the RNA bound by METT3,WTAP can be got by Myc or Flag IP followed by RNA isolation by using the TRIzol (Invitrogen) reagent by following the company manual.the RNA was then used for library preparation using a TruSeq™ RN...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-50580 | biostudies-arrayexpress
ProteomicsMethyltransferase-like 3 (METTL3) regulates exocytosis
RNA modification pathways are often mis-regulated in various typers of cancer, with N6-methyladenosine (m6A) playing a pivotal role in cancer progression and metastasis. Methyltransferase-like 3 (METTL3), a core component of the m6A methyltransferase complex, functions not only as an m6A writer but ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-04 | PXD066045 | Pride
Exoc7 Breast cancer Rna modification Vesicle trafficking Exocyst N6-methyladenosine Mettl3 
ProteomicsIdentification of METTL3 succinylation sites
The adaptation of tumor cells to metabolic stress is crucial for tumor development. We demonstrate that the translation of NRF2, a master regulator of antioxidant response, is controlled by the OGDH-METTL3 axis in melanoma for glucose starvation adaptation. To elucidate the regulatory mechanism of t...
ORGANISM(S): Homo sapiens (Human) 
2026-06-30 | PXD053934 | Pride
Succinylation Mettl3 
ProteomicsIdentification of METTL3 arginine methylation sites in CDDP-resistant Hey cells LC-MS
Previous studies have shown that nuclear localization of METTL3 is associated with CDDP resistance. To identify key PTMS involved in the nuclear localization of METTL3 in CDDP-resistant ovarian cancer cells, we assessed the global methylation of arginine, as well as METTL3 phosphorylation, acetylati...
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD061401 | Pride
Mettl3 arginine methylation sites 
ProteomicsIdentification and evaluation of oxidative phosphorylation-related genes regulated by METTL3 in gastric cancer based on proteomics and m6A methylomes
METTL3-mediated RNA N6-methyladenosine (m6A) is the most prevalent modification participates in tumor initiation and progression via regulating expression of their target genes in cancers. However, its role in tumor cell metabolism remains poorly appreciated. In this study, we conducted a multi-omic...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD036773 | Pride
Gastric cancer Oxidative phosphorylation Mettl3 M6a Prognosis 
TranscriptomicsRNA-seq of human breast cancer cell lines with METTL3 knockdown
We assess the effect of METTL3 on gene expression and transcriptional splicing in three different human breast cancer cell lines
ORGANISM(S): Homo sapiens 
2022-07-01 | E-MTAB-11664 | biostudies-arrayexpress
TranscriptomicsTranscriptomics analysis of gene expression in normal and METTL3 or WTAP deficient Human 293T cells
RNA was isolated from and METTL3M-oM-
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-50582 | biostudies-arrayexpress
TranscriptomicsGLORI mapping of m⁶A sites in human primary CD8⁺ T cells under activation and METTL3 inhibition
Glyoxal and nitrite-mediated deamination of unmethylated adenosines (GLORI) was applied to human primary CD8⁺ T cells subjected to in vitro activation with αCD3/αCD28 beads. To identify N⁶-methyladenosine (m⁶A) sites at single-nucleotide resolution and to test their dependence on METTL3, we generate...
ORGANISM(S): Homo sapiens 
2025-10-15 | E-MTAB-15649 | biostudies-arrayexpress
TranscriptomicsMETTL3 KD in HepG2 cells
To gain insight into possible processes that require m6A for their function, METTL3 was knocked down (KD) in HepG2 cells by siRNA transfections Differential expression analysis of METTL3 KD versus mock-transfected HepG2 cells, in 2 biological replicates
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37001 | biostudies-arrayexpress
TranscriptomicsMETTL3 and WTAP
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-50583 | biostudies-arrayexpress
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