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ProteomicsExocyst Dynamics During Vesicle Tethering and Fusion
The exocyst is a conserved octameric complex that tethers exocytic vesicles to the plasma membrane prior to fusion. Exocyst assembly and delivery mechanisms remain unclear, especially in mammalian cells. Here we tagged multiple endogenous exocyst subunits with sfGFP or Halo using Cas9 gene-editing, ...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-05 | PXD011370 | Pride
Vesicles Exocyst Crispr Membrane fusions 
GenomicsPancreatic Beta-Cell Enhancers Regulate Rhythmic Transcription of Exocyst Triggering and Diabetes [ChIP-seq]
The molecular clock is a transcriptional oscillator present in brain and peripheral cells that coordinates behavior and physiology with the solar cycle. Here we reveal that the clock gates insulin secretion through genome-wide transcriptional control of the pancreatic exocyst across species. Clock t...
ORGANISM(S): Mus musculus 
2015-11-10 | E-GEOD-70960 | biostudies-arrayexpress
ProteomicsCilia and the exocyst are involved in urinary extracellular vesicle production and content
A recently proposed model of cell-cell communication, called “urocrine signaling”, hypothesizes that small (50-150 mm) extracellular vesicles (EVs) carry signals to “downstream” kidney tubule cells. We previously showed that the exocyst, a highly-conserved eight-protein (Exoc1-8) trafficking complex...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2019-11-06 | PXD013549 | Pride
Gtpase Exocyst Protein trafficking Extracellular vesicle 
ProteomicsFission yeast NDR/LATS kinase Orb6 regulates exocytosis via phosphorylation of exocyst complex
NDR/LATS kinases regulate multiple aspects of cell polarity and morphogenesis from yeast to mammals, but few of their substrates are known. Fission yeast NDR/LATS kinase Orb6 has been proposed to control cell polarity via spatial regulation of Gef1, a guanine nucleotide exchange factor for the small...
ORGANISM(S): Schizosaccharomyces pombe 927 
2019-01-31 | PXD009408 | Pride
Cell polarity Fission yeast Silac Phosphoproteomics Orb6 
ProteomicsBiochemical basis of Exo70 specialization
Molecular machines comprised by multiple subunits govern essential processes in the cell. Understanding how these complexes evolve is crucial to comprehend the evolution of cellular complexity. However, our understanding on the molecular mechanisms that allow multimeric complexes to change and acqui...
ORGANISM(S): Marchantia polymorpha subsp. ruderalis 
2025-12-01 | PXD051853 | Pride
Exocyst  cell trafficking  evolution  marchantia polymorpha  biomolecular condensates  protein complexes. 
ProteomicsExocyst Subunit Exo70B2 is Linked to Immune Signalling and Autophagy
During the immune response, activation of the secretory pathway is key to mount an effective response, while gaging its output is important to maintain cellular homeostasis. Exo70 subunit of the exocyst functions as a spatiotemporal regulator by mediating numerous interactions with proteins and lipi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-03-01 | PXD022246 | Pride
Autophagy Secretion Phosphorylation Atg8 Signalling Exo70b2 Vacuole 
UnknownExorcising the exocyst complex.
Not available
S-EPMC3374049 | biostudies-literature
UnknownThe exocyst complex in neurological disorders.
Not available
S-EPMC10449956 | biostudies-literature
ProteomicsMutations in the exocyst component EXOC2 (Sec5) cause severe defects in human brain development
The exocyst is an octameric protein complex and an essential component of the membrane transport machinery required for tethering vesicles at the plasma membrane prior to fusion. Here we report on pathogenic variants in one of the exocyst subunits, EXOC2 (Sec5), in unrelated families. Analysis of pa...
ORGANISM(S): Homo sapiens (Human) 
2020-06-29 | PXD017107 | Pride
Human Exoc2 Fibroblasts Tmt6plex 
UnknownExocyst dynamics during vesicle tethering and fusion.
Not available
S-EPMC6277416 | biostudies-literature
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