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ProteomicsTomato (Solanum lycopersicum) lysine succinylation LC-MS/MS
Post-translational modification of proteins through lysine succinylation plays important regulatory roles in living cells. Lysine succinylation was recently identified as a novel post-translational modification in several organisms, including Escherichia coli, yeast, Toxoplasma gondii, and HeLa cell...
ORGANISM(S): Alternaria tomato 
2018-10-24 | PXD002380 | Pride
Tomato Lysine succinylation Lc-ms/ms 
ProteomicsSuccinylation proteome analysis of seedling leaves of Bd21
Protein lysine succinylation, an emerging protein post-translational modification widespread among microbiology, animals and plants, represents an important regulator of cellular processes. In our study, we took the first succinylation proteome analysis in the seedling leaves of Bd21 to draw a schem...
ORGANISM(S): Brachypodium distachyon (Purple false brome) (Trachynia distachya) 
2018-10-26 | PXD003428 | Pride
Succinylation analysis seedling leaves of bd21 
ProteomicsLysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation
Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about their scope and cellular distribution. We mapped thousands of succinylation sites in bacteria (E. coli), yeast (S. cerevisiae), human...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2015-06-02 | PXD002277 | Pride
Yeast Human Liver Bacteria Mouse Succinylation Acetylation 
ProteomicsSuccinylation profiles of brain injury after intracerebral hemorrhage
Protein posttranslational modifications (PTMs) has been shown to regulate biological processes of human diseases via expanding the genetic code and for regulating cellular pathophysiology, however, the system-wide changes at the PTMs levels in ICH brain remains little known. Given that succinylation...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-29 | PXD025621 | Pride
Intracerebral hemorrhage  brain injury  succinylation 
ProteomicsCarnitine palmitoyltransferase 1A promotes mitochondrial fission by enhancing MFF succinylation in ovarian cancer
Mitochondria are dynamic organelles that are important for cell growth and proliferation. Dysregulated mitochondrial dynamics are highly associated with the initiation and progression of various cancers, including ovarian cancer. However, the regulatory mechanism underlying mitochondrial dynamics is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-15 | PXD041990 | Pride
Mitochondrial dynamics  mff  succinylation  ovarian cancer 
ProteomicsSuccinylome analysis reveals the involvement of lysine succinylation in extreme resistance of Deinococcus radiodurans
Increasing evidences showing that succinylation of lysine residue mainly regulates enzymes involved in the carbon metabolism pathway, both in prokaryotic and eukaryotic cells. Deinococcus radiodurans is one of the most radioresistant organisms on earth, which is famous for its robust resistance. A m...
ORGANISM(S): Deinococcus radiodurans 
2021-04-26 | PXD012149 | Pride
Succinylome  succinylation  dna repair  nucleic acid binding  posttranslational modification 
ProteomicsHuman prostate cancer and Lysine succinylation
: Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide. Among patients who developed advanced PCa, 80% suffered from bone metastasis, with a sharp drop in the survival rate. Using quantitative global succinylome analysis, we characterized a significant increase of ly...
ORGANISM(S): Homo sapiens (Human) 
2023-06-21 | PXD022005 | Pride
Prostate cancer Lysine succinylation Metastasis 
ProteomicsProteomic Analysis of Lysine Succinylation in oryza sativa
By the combination of affinity enrichment and high-resolution LC-MS/MS analysis, large-scale lysine succinylome analysis was performed. Altogether, 742 lysine succinylation sites in 382 protein groups were identified. Intensive bioinformatic analyses were then carried out to annotate those identifie...
ORGANISM(S): Oryza sativa (Rice) 
2018-10-26 | PXD005582 | Pride
Oryza sativa succinylation 
ProteomicsFirst Comprehensive Proteome Analyses of Lysine Succinylation in Physalis angulata, a medicinal plant with a high pharmaceutical value
Physalis angulata is a medicinal plant with a high pharmaceutical value that is widely cultivated in East Asia. Lysine succinylation, a newly identified post-translational modification, is associated with various cellular processes. However, the regulatory mechanism underlying the metabolism of P. a...
ORGANISM(S): Physalis angulata 
2019-11-08 | PXD006778 | Pride
Physalis angulata Proteome Succinylation 
ProteomicsComprehensive Succinylome Profiling Reveals the Pivotal Role of Lysine Succinylation in Energy Metabolism and Quorum Sensing of Staphylococcus epidermidis
Background: Lysine succinylation is a newly identified PTM, which exists widely from prokaryotes to eukaryotes and participates in various cellular processes, especially in the metabolic processes. Staphylococcus epidermidis is a commensal bacterium in the skin, which attracts more attention as a pa...
ORGANISM(S): Staphylococcus epidermidis 
2021-02-25 | PXD022866 | Pride
Post-translational modification  lysine succinylation  staphylococcus epidermidis  energy metabolism  succinyltransferase  desuccinylase  quorum sensing 
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