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TranscriptomicsExpression profiles of wildtype and Shox2 knockout embryonic limbs
The development of vertebrate extremities is a complex process which requires a highly coordinated network of different transcriptional activities. The homeodomain transcription factor Shox2 is a key player in limb formation controlling neural, muscular and skeletal development. Here, we compared ge...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-41945 | biostudies-arrayexpress
GenomicsSequencing of iMDK-treated regenerating limbs
Sequencing of iMDK-treated regenerating limbs
PRJNA547606 | ENA
TranscriptomicsDifferenetial Gene Expression in Limbs of Wild Type and Lmx1b KO mice during limb dorsalization (e11.5, e12.5 & e13.5)
Lmx1b regulates dorsalization of limb fates, but the mechanism of this regulation has not been characterized. To identify candidate genes regulated by Lmx1b we compared the limbs from Lmx1b KO mice to wild type mice during limb dorsalization (e11.5-13.5). Differentially expressed genes that we com...
ORGANISM(S): Mus musculus 
2012-05-21 | E-GEOD-34732 | biostudies-arrayexpress
TranscriptomicsExpression profiles of wildtype and SHOX transgenic embryonic mouse limbs
Deficiency of the human short stature homeobox-containing gene (SHOX) has been identified in several disorders characterized by reduced height and skeletal anomalies such as Turner, Leri-Weill and Langer syndrome as well as idiopathic short stature. Although highly conserved in vertebrates, rodents ...
ORGANISM(S): Mus musculus 
2014-08-13 | E-GEOD-47902 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional landscape of human embryonic limb development - Mouse
To investigate into the evolutionary conversation of the single-cell transcriptome of human fetal limbs, especially the principles of forelimb and hindlimb specification and proximal-distal axis establishment, we collected the forelimbs and hindlimbs of mouse embryos matching human samples. We disse...
ORGANISM(S): Mus musculus 
2022-04-15 | E-MTAB-10514 | biostudies-arrayexpress
GenomicsChromatin conformation of the Shh locus in limbs.
Expression of Shh in the limb is dependent on a distant enhancer located 850kb away from the gene promoter. We performed chromatin conformation capture (4C-Seq) analysis of the Shh locus in E11.5 mouse limbs so as to better understand the relationship between this regulatory interaction and the stru...
ORGANISM(S): Mus musculus 
2017-01-12 | E-MTAB-4980 | biostudies-arrayexpress
GenomicsRegulation of Ptch1 expression in the limb
Ptch1 is a critical negative feedback regulator of the Hedgehog signaling and is upregulated in response to pathway activation. How tissue specific responses are mediated remains unknown. Here, we performed ChIP-seq analysis for epitope-tagged endogenous Gli3 protein to identify limb-specific bindin...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-52939 | biostudies-arrayexpress
GenomicsChromatin conformation of the Shh locus in limbs.
Chromatin conformation of the Shh locus in limbs.
PRJEB14953 | ENA
TranscriptomicsSingle-cell transcriptional landscape of human embryonic limb development
Human limbs emerge during the fourth post-conception week as mesenchymal buds, which develop into fully formed limbs over the subsequent months. This process is orchestrated by numerous temporally and spatially restricted gene expression programmes, making congenital alterations in phenotype common....
ORGANISM(S): Homo sapiens 
2022-04-15 | E-MTAB-8813 | biostudies-arrayexpress
UnknownIntestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery.
Not available
S-EPMC11750664 | biostudies-literature
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