An early event in lung oncogenesis is loss of the tumour suppressor gene LIMD1 (LIM domains containing 1); this encodes a scaffold protein, which binds multiple binding partners to suppress tumourigenesis via a number of different mechanisms. Approximately 45% of non-small cell lung cancers (NSCLC) ...
To understand mRNA abundance changes in LIMD1 deficient human SAEC cells, we performed bulk mRNA-seq on Ctrl, LIMD1 Het, and LIMD1 KO (CRISPR-Cas9 edited) hSAECs.
LIMD1 is a tumour suppressor commonly found to have loss-of-function mutations in lung adenocarcinoma patients. Here we explore potential vulnerabilities of a lung cancer cell line specific to LIMD1 loss.
Transforming growth factor (TGF)-β signaling enhances cancer cell plasticity by inducing epithelial-to-mesenchymal transition (EMT). Here, we identified a TGF-β-induced long non-coding RNA, LIMD1 Antisense RNA 1 (LIMD1-AS1) that strengthens the SMAD-mediated transcriptional response to TGF-β. LIMD1-...
