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ProteomicsCovalent targeting leads to the development of LIMK1 isoform-selective inhibitors
SM311 is a covalent LIMK1 inhibitor. To verify the specificity of SM311 towards LIMK1, a chemoproteomic competition experiment was set up with a biotin adduct of SM311, namely SM429. This adduct was immobilised on Streptactin beads and used to enrich proteins binding to SM429. Preincubation with an ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD063179 | Pride
Chemoproteomics Kinase Limk1 Human 
TranscriptomicsTranscription profiling of human A549 lung cancer cells treated with compounds from a series of inhibitors developed against the human LIM kinases LIMK1 and LIMK2
To investigate an unknown mechanism of cytotoxicity, A549 human lung-cancer cells were treated with compounds from a series of inhibitors developed against the human LIM kinases LIMK1 and LIMK2. Compounds 1 and 2 inhibit LIM kinase activity in vitro and affect cell proliferation and survival in vivo...
ORGANISM(S): Homo sapiens 
2008-09-17 | E-TABM-450 | biostudies-arrayexpress
UnknownLIMK1: A promising prognostic and immune infiltration indicator in colorectal cancer.
Not available
S-EPMC9185146 | biostudies-literature
UnknownLIMK1/2 inhibitor LIMKi 3 suppresses porcine oocyte maturation.
Not available
S-EPMC5068415 | biostudies-literature
UnknownLIMK1 is a prognosis and treatment biomarker in hepatocellular carcinoma.
Not available
S-EPMC12475169 | biostudies-literature
UnknownLessons from LIMK1 enzymology and their impact on inhibitor design.
Not available
S-EPMC6835155 | biostudies-literature
UnknownLIMK1 promotes peritoneal metastasis of gastric cancer and is a therapeutic target.
Not available
S-EPMC8116207 | biostudies-literature
UnknownLIMK1 variants are associated with divergent endocrinological phenotypes and altered exocytosis dynamics.
Not available
S-EPMC12146536 | biostudies-literature
UnknownUpregulation of LIMK1 Is Correlated With Poor Prognosis and Immune Infiltrates in Lung Adenocarcinoma.
Not available
S-EPMC8209497 | biostudies-literature
UnknownCovalent Targeting Leads to the Development of a LIMK1 Isoform-Selective Inhibitor.
Not available
S-EPMC12305648 | biostudies-literature
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