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GenomicsChIP-seq for CTCF and Rad21 in Rag1M-bM-^HM-^R/M-bM-^HM-^R pro-B cells
Genome-wide ChIP data of CTCF and Rad21 binding in Rag1M-bM-^HM-^R/M-bM-^HM-^R pro-B cells CTCF and Rad21 binding in Rag1M-bM-^HM-^R/M-bM-^HM-^R pro-B
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-26257 | biostudies-arrayexpress
TranscriptomicsA global network of transcription factors, involving E2A, EBF1 and FOXO1, that orchestrates the B cell fate
It is now established that the transcription factors E2A, EBF1 and FoxoM-BM- 1 play critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1 as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis...
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-21978 | biostudies-arrayexpress
TranscriptomicsSimple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21512 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of WT bone marrow myeloid progenitors, BM cultured with GM-CSF and M-CSF, and monocytes treated with GM-CSF
Analysis of genes induced in DC precursors and in BM cells and monocytes treated with GM-CSF For progenitor arrays, bone marrow progenitors (CMP, GMP, CDP, and pre-cDC) were harvested from WT C57Bl/6 mice. For culture arrays, BM was cultured in the presence of GM-CSF or M-CSF and adherent and non-a...
ORGANISM(S): Mus musculus 
2012-05-20 | E-GEOD-37029 | biostudies-arrayexpress
TranscriptomicsIdentification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition [PAR-CLIP]
Human LIN28A and B are RNA-binding proteins (RBPs) conserved in animals with important roles during development and stem cell reprogramming. We used Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation (PAR-CLIP) in HEK293 cells and identified a largely overlapping set of ~3...
ORGANISM(S): Homo sapiens 
2013-02-26 | E-GEOD-44615 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human precursor-B-cell differentiation
We purified five subsets representing the main stages of human precursor-B-cell differentiation and CD34+lin- cord blood cells. The immunoglobulin (Ig) gene rearrangement status was determined using TaqMan quantitative PCR and GeneScan analysis. To gain more insight in the networks of genes that ini...
ORGANISM(S): Homo sapiens 
2005-10-01 | E-MEXP-384 | biostudies-arrayexpress
TranscriptomicsLIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance
This SuperSeries is composed of the following subset Series: GSE39855: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (splicing array) GSE39872: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (HTS) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-09-10 | E-GEOD-39873 | biostudies-arrayexpress
TranscriptomicsThe transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program
Mature lymphoid cells express the transcriptional repressor Bach2, which imposes regulation on humoral and cellular immunity. Here we found critical roles for Bach2 in the development of cells of the B lineage, commencing from the common lymphoid progenitor (CLP) stage, with Bach1 as an auxiliary. O...
ORGANISM(S): Mus musculus 
2014-10-26 | E-GEOD-61409 | biostudies-arrayexpress
TranscriptomicsBile acids promote adenocarcinoma in a novel transgenic mouse model of BarrettM-bM-^@M-^Ys esophagus
Esophageal adenocarcinoma (EAC) has the fastest increase of any cancer in the US and Europe, and arises in the setting of BarrettM-bM-^@M-^Ys esophagus (BE), defined by replacement of normal squamous epithelium with columnar intestinal-like epithelium. BE is thought to result from chronic esophagea...
ORGANISM(S): Mus musculus 
2011-01-31 | E-GEOD-24931 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human WhartonM-bM-^@M-^Ys jelly stem cells
Human WhartonM-bM-^@M-^Ys jelly stem cells (hWJSCs) are derived ethically in large amounts from the umbilical cord matrix. Besides their differentiation capabilities, WJSCs also display a notable lack of ability to form teratoma. hWJSCs have been shown to exert immunomodulatory effects and have rece...
ORGANISM(S): Homo sapiens 
2010-07-25 | E-GEOD-20126 | biostudies-arrayexpress
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