Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

ABSTRACT: Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including targeting of transcription factors to accessible chromatin marked by lysine 4-monomethylated histone H3 (H3K4me1) and interactions between transcription factors that enable nucleosome displacement. Here we demonstrate that collaborative interactions of PU.1 with small sets of macrophage- or B cell-lineage-determining transcription factors establish common and cell-specific binding sites that are associated with the majority of promoter-distal H3K4me1-marked genomic regions in macrophages and B ce

ORGANISM(S): Mus musculus

SUBMITTER: Christopher Benner 

PROVIDER: E-GEOD-21512 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress