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ProteomicsHuman Rheumatoid Arthritis LC-MSMS
Malondialdehyde-modified epitopes (MDA-epitopes) can elicit specific autoantibody that expressed oxidative stress arising in rheumatoid arthritis (RA). The purpose of this study was to discover and validate MDA-peptide adducts as novel biomarkers using concanavalin A affinity chromatography, 1D SDS-...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD004546 | Pride
Serum Rheumatoid arthritis Malondialdehyde Autoantibody isotypes 
ProteomicsThe Pathogenic Role of Novel Anti-malondialdehyde Modified-peptide Adduct Autoantibodies in Plasma and Importing Machine Learning for Predicting Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus
The goals of this study will valid and investigate levels of MDA, MDA-modified protein, and MDA-modified peptide adducts and their autoantibody isotypes.
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD046723 | Pride
Coronary artery stenosis Plasma Coronary artery disease in patients with type 2 diabetes mellitus Malondialdehyde Autoantibody isotypes 
TranscriptomicsGene expression data for MACS-isolated primary splenic T cells
We are interested in unveiling potential gene expression alterations underlying the T cell-related phenotypes observed in DUSP4-/- mice. We used microarray to obtain a macroscopic views of gene profiles comparing freshly isolated splenic T cells from WT and DUSP4-/- mice Magnetic-assisted cell sorti...
ORGANISM(S): Mus musculus 
2016-02-25 | E-GEOD-75319 | biostudies-arrayexpress
ProteomicsClinical Assay for the Early Detection of Colorectal Cancer Using Mass Spectrometric Wheat Germ Agglutinin Multiple Reaction Monitoring
Colorectal cancer (CRC) is currently the third leading cause of cancer related mortality in the world. U.S. Food and Drug Administration-approval circulating tumor markers, including carcinoembryonic antigen, carbohydrate antigen (CA) 19-9 and CA125, were used as prognostic biomarker of CRC that att...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD024997 | Pride
Colorectal cancer  multiple reaction monitoring  tandem mass spectrometer  wheat germ agglutinin  plasma 
ProteomicsHNE-modification identification of ApoAI
In this research, two 4-hydroxy-2-nonenal modified peptides with differential performance were identified in the plasma of patients with coronary artery disease, whether their antibodies were different in the plasma of patients with coronary artery disease and healthy people.
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD041969 | Pride
Two 4-hydroxy-2-nonenal Apolipoprotein ai Coronary artery disease Autoantibody 
TranscriptomicsA long noncoding RNA protects the heart from pathological hypertrophy
The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo antisense transcription1, including myosin heavy chain 7 (Myh7), which encodes molecular motor proteins for heart contraction2. Her...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-49716 | biostudies-arrayexpress
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
TranscriptomicsDNMT3L promotes quiescence in postnatal spermatogonial progenitor cells
We analyzed transcriptome profiles of postnatal germ cells and demonstrated that DNMT3L is important for spermatogonial stem/progenitor cell development Examination of wild-type and Dnmt3l knockout smaples in postnatal male germ cells
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-54411 | biostudies-arrayexpress
Genomicsena-DATASET-GoT2D/T2D-GENES-09-07-2016-02:03:47:226-1135 - samples
The GoT2D study includes ~2800 samples, half T2D cases and half T2D controls, of Northern European ancestry sequenced over 3 three technologies: deep whole exome sequencing, low-pass (4x) whole genome sequencing, and OMNI 2.5M genotyping. Samples were ascertained to be phenotypically "extreme" (e.g....
EGAD00001002247 | EGA
GenomicsImputation analysis file
This data set includes the following summary level data file used for the imputation data: imputation.sv.assoc.txt: results from single variant association analysis in imputed samples
EGAD00010001184 | EGA
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