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ProteomicsSerum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes
Aims/hypothesis: Biomarkers are needed to accurately predict and monitor type 1 diabetes progression during the substantially heterogeneous presymptomatic period of the disease development. To address this concern, we studied temporal changes in the plasma and serum proteomes of < 5-year-old childre...
ORGANISM(S): Homo Sapiens 
PXD033946 | panorama
ProteomicsSERPA: Autoantibody profiling in POAG
Glaucoma is the leading cause of irreversible blindness worldwide. An early diagnosis of the disease is crucial for treatment success. Mechanisms behind glaucoma pathogenesis are not completely understood, but disease related alterations in the serological autoantibody profile indicate an immunologi...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2019-02-21 | PXD011752 | Pride
Autoantibodies  serpa  immunoproteomics  glaucoma  poag 
ProteomicsMultiomics Profiling of Alzheimer’s Disease Serum for the Identification of Autoantibody Biomarkers
New biomarkers of Alzheimer’s Disease (AD) with diagnostic value in preclinical and prodromal stages are urgently needed. AD-related serum autoantibodies are potential candidate biomarkers. Here, we aimed at identifying AD-related serum autoantibodies using protein microarrays and mass spectrometry-...
ORGANISM(S): Homo sapiens (Human) 
2021-12-20 | PXD028392 | Pride
Mass spectrometry Prest microarrays Autoantigens Alzheimer's disease Protein microarrays Autoantibodies 
TranscriptomicsGenome-wide expression kinetics of children with T1D-associated autoantibodies compared to healthy matched controls II
To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis. 58 peripheral blood ...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-30209 | biostudies-arrayexpress
TranscriptomicsCell intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses
Endosomal Toll-like receptors (TLRs) play an important role in the etiology of systemic autoimmune diseases such as SLE, where DNA- and RNA-associated autoantigens activate autoreactive B cells through TLR9- and TLR7-dependent pathways, respectively. Nevertheless, TLR9-deficient autoimmune prone mic...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-58756 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression kinetics of children with T1D-associated autoantibodies compared to healthy matched controls I
To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis. 63 peripheral blood ...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-30208 | biostudies-arrayexpress
UnknownThe promise, perceptions, and pitfalls of immunoassays for autoantibody testing in myositis.
Not available
S-EPMC7227250 | biostudies-literature
TranscriptomicsGene Expression Profiles in a Rabbit Model of Systemic Lupus Erythematosus
We previously reported the establishment of a rabbit (Oryctolagus cuniculus) model of Systemic Lupus Erythematosus (SLE) in which peptide immunization led to lupus-like autoantibody production including anti-Sm, -RNP, -SS-A, -SS-B and -dsDNA. Some neurological symptoms in form of seizures and nystag...
ORGANISM(S): Oryctolagus cuniculus 
2010-07-23 | E-GEOD-23076 | biostudies-arrayexpress
GenomicsIdentification of an autoantibody promoting the development of Sjögren's Syndrome-like sialadenitis
Identification of an autoantibody promoting the development of Sjögren's Syndrome-like sialadenitis
PRJNA1053421 | ENA
ProteomicsUnderstanding early AutoAb signatures in Pituitary Adenomas using CDI HuProt™ (Human Proteome Microarray)
CDI HuProt™ (Human Proteome Microarray), was used to study Pituitary Adenomas PAs (Acromegaly, Cushing's and NFPA) using serum samples, from around 14 individuals (4 Healthy control, 4 Acromegaly, 3 Cushing’s and 3 NFPAs patient samples) were used study their autoantibody profiles. Patient serum sam...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-11947 | biostudies-arrayexpress
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