Sort   by:  
 Page size 
TranscriptomicsThe Function of Piwi is Independent of Its Slicer Activity
In diverse organisms, the highly-conserved Piwi proteins bind to a complex class of small non-coding RNAs called piRNAs, and are essential for germline stem cell maintenance, transposon silencing, fertility, and offspring viability1. By homology with other Argonautes, Piwi proteins have been propose...
ORGANISM(S): Drosophila melanogaster 
2013-02-04 | E-GEOD-34032 | biostudies-arrayexpress
TranscriptomicsPIWI-associated piRNA in Drosophila melanogaster ovary
Heterochromatin, representing the silenced state of transcription, largely consists of transposon-enriched and highly repetitive sequences. Implicated in heterochromatin formation and transcriptional silencing in Drosophila are PIWI and repeat-associated small interfering RNAs (rasiRNAs). Despite th...
ORGANISM(S): Drosophila melanogaster 
2007-10-24 | E-GEOD-9138 | biostudies-arrayexpress
ProteomicsPUMILIO Proteins in Colorectal Cancer: Tumor Growth Promoting Function and Potential as Therapeutic Targets
We employ Mass spectrum to investigate proteome of Pum1-Knockout, Pum2-Knockout and WT conditions in human colorectal cancer cell line Hct116. Overall design: In order to investigate whether Pum1 and Pum2 regulate their targets at their protein levels, we used Pum1-Knockout, Pum2-Knockout and WT Hct...
ORGANISM(S): Homo Sapiens 
2021-07-23 | PXD027513 |
TranscriptomicsThe role of PIWIL4 in breast cancer
PIWI proteins bind to PIWI-interacting RNAs (piRNAs) and play key roles in the biogenesis and functions of piRNAs. It has been reported that PIWI proteins are essential for stem cell self-renewal and germline development in diverse organisms, and are ectopically expressed in multiple forms of cancer...
ORGANISM(S): Homo sapiens 
2016-03-08 | E-GEOD-78238 | biostudies-arrayexpress
Sort   by:  
 Page size