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MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
TranscriptomicsStrand-specific RNA-seq of 13 human tissues from Michael Snyder's lab for the ENCODE project
This ArrayExpress experiment contains RNA-seq data from human tissues, generated by Michael Snyder's lab at Stanford University as part of the ENCODE project ( https://www.encodeproject.org/search/?type=Experiment ). Sample information was obtained from the ENCODE data coordination center and proto...
ORGANISM(S): Homo sapiens 
2016-01-21 | E-MTAB-4344 | biostudies-arrayexpress
TranscriptomicsSite-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Physiologically, Notch signal transduction plays a pivotal role in differentiation; pathologically, Notch signaling contributes to the development of cancer. Transcriptional activation of Notch target genes involves cleavage of the Notch receptor in response to ligand binding, production of the Notc...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-62528 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of murine ITPKB deficient versus wild type LT-HSC
Tight regulation of hematopoietic stem cell (HSC) homeostasis is essential for life-long hematopoiesis, for preventing blood cancers and for averting bone marrow failure. The underlying mechanisms are incompletely understood. Here, we identify production of inositol-tetrakisphosphate (IP4) by inosit...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-56613 | biostudies-arrayexpress
UnknownExpression of non-phosphorylatable S5A-L-plastin exerts phenotypes distinct from L-plastin deficiency during podosome formation and phagocytosis.
Not available
S-EPMC10150066 | biostudies-literature
TranscriptomicsP19 cells+LIN28_RA-differentiated_Day 4
LIN28 is an RNA-binding protein expressed in many developing tissues. It can block let-7 microRNA processing and help promote pluripotency. We observe LIN28 expression in the developing neural tube, colocalizing with SOX2, suggesting a role in neural development. To better understand its normal deve...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-19705 | biostudies-arrayexpress
ProteomicsA Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent that Suppresses Tumor Metastasis
Drug target identification is a critical step towards the understanding of the mechanism of action of a drug, which will help to improve the current therapeutic regime and to expand the drug’s therapeutic potential. However, current in vitro affinity chromatography-based and in vivo activity- based ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-28 | PXD000588 | Pride
Chemical biology  drug targets*  itraq  mass spectrometry Molecular probes*   antitumor agents  metastasis 
UnknownAlterations of the gut mycobiome in patients with MS.
Not available
S-EPMC8399064 | biostudies-literature
UnknownRanking age-specific modifiable risk factors for cardiovascular disease and mortality: evidence from a population-based longitudinal study.
Not available
S-EPMC10626167 | biostudies-literature
UnknownAlterations of host-gut microbiome interactions in multiple sclerosis.
Not available
S-EPMC8814376 | biostudies-literature
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