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GenomicsGenome-wide chromatin maps of T-cell acute lymphoblastic leukemia (T-ALL) [ChIP-seq]
Here we modeled T-ALL resistance to Notch inhibition, identifying M-bM-^@M-^XpersisterM-bM-^@M-^Y cells that readily expand in the presence of gamma secretase inhibitor (GSI) and the absence of Notch signaling. Rare persister cells are already present in naM-CM-/ve T-ALL populations, and the reversi...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54379 | biostudies-arrayexpress
ProteomicsExome-based proteogenomics of HEK-293 human cell line: coding genomic variants identified at the level of shotgun proteome
Genomic and proteomic data were integrated into the proteogenomic workflow to identify coding genomic variants of Human Embryonic Kidney 293 (HEK-293) standard cell line at the proteome level. Shotgun proteome data published by Geiger et al (2012) and obtained in this work for HEK-293 were searched ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080712 | MassIVE
TranscriptomicsLIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance
This SuperSeries is composed of the following subset Series: GSE39855: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (splicing array) GSE39872: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (HTS) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-09-10 | E-GEOD-39873 | biostudies-arrayexpress
UnknownDecreased expression of mitochondrial miR-5787 contributes to chemoresistance by reprogramming glucose metabolism and inhibiting MT-CO3 translation.
Not available
S-EPMC6735381 | biostudies-literature
TranscriptomicsExpression data from human hematopoietic stem and progenitor compartments from patients with acute myeloid leukemia with normal karyotype and healthy controls
We applied a novel approach of parallel transcriptional analysis of multiple, highly fractionated stem and progenitor populations from patients with acute myeloid leukemia (AML) and a normal karyotype. We isolated phenotypic long-term HSC (LT-HSC), short-term HSC (ST-HSC), and committed granulocyte-...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-35008 | biostudies-arrayexpress
TranscriptomicsMyeloid derived suppressor cells enhance stemness of cancer cells by inducing miRNA101 and suppressing the corepressor CtBP2
The work identifies an immune associated cellular, molecular and clinical network involving MDSCs-microRNA101-CtBP2-stem cell core genes, which extrinsically controls cancer stemness and impacts patient outcome. Primary ovarian cancer cells (5 x105) were co-cultured with freshly sorted ovarian cance...
ORGANISM(S): Homo sapiens 
2013-08-23 | E-GEOD-50082 | biostudies-arrayexpress
TranscriptomicsLIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (HTS)
LIN28 is a conserved RNA binding protein implicated in pluripotency, reprogramming and oncogenesis. Previously shown to act primarily by blocking let-7 microRNA (miRNA) biogenesis, here we elucidate distinct roles of LIN28 regulation via its direct messenger RNA (mRNA) targets. Through cross-linking...
ORGANISM(S): Homo sapiens 
2012-09-10 | E-GEOD-39872 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of LSK (lineage negative, Sca-1+, c-Kit+) cells isolated by fluorescence-activated cell sorting from the bone marrow of control young C57Bl/6Jax mice
Hematopoietic stem cells (HSCs) and different multipotent progenitor populations (MPPs) contained in the Lin- Sca-1+ c-Kit+ (LSK) compartment have previously been identified using diverse surface marker panels. However, a comprehensive and complete characterization of the complete LSK compartment is...
ORGANISM(S): Mus musculus 
2021-05-13 | E-MTAB-9208 | biostudies-arrayexpress
TranscriptomicsscRNA-seq from Trex1 KO in tumor
Single-cell RNA-seq data for Trex1 WT and KO mice from the tumor. Used for manuscript in submission at Science Advances.
ORGANISM(S): Mus musculus 
2026-03-25 | E-MTAB-16526 | biostudies-arrayexpress
UnknownInfection-induced endothelial amyloids impair memory.
Not available
S-EPMC6704457 | biostudies-literature
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