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TranscriptomicsThe Mi-2 homolog, Mit1, actively positions nucleosomes within heterochromatic domains to suppress transcription
Nucleosome positioning is both active and passive and regulates access to the genome for replication, transcription and repair. Here we report that Mit1, a subunit of the fission yeast SHREC complex similar to Mi-2/NuRD, regulates transcription at regions of heterochromatin by positioning nucleosome...
ORGANISM(S): Schizosaccharomyces pombe 
2014-04-08 | E-GEOD-46649 | biostudies-arrayexpress
TranscriptomicsPopulation RNA Seq of long-term HSCs isolated from mice after myocardial infarction (day 2 post infarct) or sham surgery and at-RA treatment or DMSO control treatment
Study of the effects of at-RA treatment on the transcriptome of murine Long-Term Hematopoietic Stem Cells (LT-HSCs) in the context of myocardial infarction (MI). MI was induced in female C57BL/6J mice aged 6 to approximately 12 weeks through permanent occlusion of the left anterior descending artery...
ORGANISM(S): Mus musculus 
2025-02-06 | E-MTAB-13506 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of bone marrow cells and spleen isolated from mice after sham surgery or myocardial infarction, followed by treatments (vehicle/4-oxo-RA)
Study of the impact of 4-oxo-RA on LSK (bone marrow and spleen) cell characteristics post-myocardial infarction in C57BL/6J mice. Myocardial infarction was induced in female C57BL/6J mice (aged 6 to approximately 12 weeks) through LAD occlusion. Post-surgery, mice were intraperitoneally injected wit...
ORGANISM(S): Mus musculus 
2025-02-06 | E-MTAB-13510 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of bone marrow cells isolated from RarB KO mice after sham surgery or myocardial infarction, followed by treatments (vehicle/4-oxo-RA)
Study of the impact of 4-oxo-RA on LSK cell characteristics post-myocardial infarction in RarB KO mice. Myocardial infarction was induced in female RarB KO mice aged 6 to 12 weeks by LAD occlusion. On the 1st and 2nd post-MI days, mice were intraperitoneally injected with 30 mg/kg 4-oxo-RA (MI+4-oxo...
ORGANISM(S): Mus musculus 
2025-02-06 | E-MTAB-13511 | biostudies-arrayexpress
ProteomicsMi-2β promotes immune evasion in melanoma by activating EZH2 methylation
For identification of Mi-2β-interacting proteins, B16F10 cells (1 × 108) were collected and washed three times with PBS and lysed in lysis buffer on ice for 30 min. Cell lysates were collected and then isolated over night by anti-Mi-2β magnetic agarose beads. The anti-Mi-2β magnetic agarose beads we...
ORGANISM(S): Mus Musculus 
2024-02-18 | PXD049467 |
ProteomicsPhosphoproteomic Analysis Reveals Molecular Signatures of Myocardial Infarction and Transverse Aortic Constriction in Aged Mouse Models
Project description: In this study, we performed proteome analyses to identify the key molecules that participate in aged mouse models of MI and transverse aortic constriction (TAC), the latter of which mimics increased left ventricular afterload that in the clinical setting predominantly occurs owi...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD044254 | Pride
Hypertension  myocardial infarction  aging  phosphoproteome 
ProteomicsProteomic Analysis Reveals Molecular Signatures of Myocardial Infarction and Transverse Aortic Constriction in Aged Mouse Models
Project description: In this study, we performed proteome analyses to identify the key molecules that participate in aged mouse models of MI and transverse aortic constriction (TAC), the latter of which mimics increased left ventricular afterload that in the clinical setting predominantly occurs owi...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD044253 | Pride
Hypertension  myocardial infarction  aging  proteome 
UnknownDifferent Mi-2 complexes for various developmental functions in Caenorhabditis elegans.
Not available
S-EPMC2965115 | biostudies-literature
ProteomicsBone Morphogenetic Protein 9 Protects against Myocardial Infarction by Improving Lymphatic Drainage Function and Triggering DECR1-Mediated Mitochondrial Bioenergetics
We investigated the impact of both BMP9 deficiency and replenishment on the pathogenesis of MI in mice. Our results showed an aggravated pathological phenotype of MI in BMP9 knockout (KO) mice, which can be alleviated by replenishment of BMP9. Therefore, we further investigated the mechanism whereby...
ORGANISM(S): Mus Musculus 
2024-04-17 | PXD051517 |
MetabolomicsEssential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Omega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n...

2020-11-03 | MTBLS1952 | MetaboLights
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