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UnknownIdentification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Cells in Ph+ CML.
Not available
S-EPMC4817228 | biostudies-literature
TranscriptomicsTime course profile of umbilical cord blood cells in culture
Despite the importance of inter-cellular communication networks in regulating stem cell fate decisions, very little is known about the topology, dynamics, or functional significance. Using human blood stem cell cultures as an experimental paradigm, we present a novel bioinformatic approach to integ...
ORGANISM(S): Homo sapiens 
2009-07-01 | E-GEOD-16589 | biostudies-arrayexpress
Genomics5-Hydroxymenthylation-associated Epigenetic Modifiers in Alzheimer's disease
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive deterioration of cognitive function. Evidence suggests a role for epigenetic regulation, in particular the cytosine modifications 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC,) in AD. 5hmC is hi...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-72782 | biostudies-arrayexpress
TranscriptomicsFrequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line
Epigenetic reprogramming is commonly observed in cancer, and is hypothesized to involve multiple mechanisms, including DNA methylation and Polycomb repressive complexes (PRCs). Here we devise a new experimental and analytical strategy using customized high density tiling arrays to investigate coordi...
ORGANISM(S): Homo sapiens 
2008-08-07 | E-GEOD-12334 | biostudies-arrayexpress
GenomicsChiP-seq profiling of Drosophila melanogaster salivary glands to identify targets for NSL1 and MCRS2.
ChiP-seq profiling of Drosophila melanogaster salivary glands to identify targets for NSL1 and MCRS2.
ORGANISM(S): Drosophila melanogaster 
2010-06-25 | E-MTAB-214 | biostudies-arrayexpress
ProteomicsAn integrated approach to profile lung tumor endothelial cell heterogeneity across species and models and to identify angiogenic candidates
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse) and models (in vivo/vitro) remains poorly inventoried at the single-cell-level. We single-cell RNA-sequenced 56,771 ECs from human/mouse (peri)-tumoral lung and cultured human lung TECs, detected 17 ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD014123 | Pride
Endothelial cells  endothelial heterogeneity  cancer  single cell rna-sequencing  multi-omics  angiogenesis  anti-angiogenic therapy 
TranscriptomicsThe histone chaperone CAF-1 safeguards somatic cell identity during transcription factor-induced reprogramming
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-66534 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse erythroid tissue with RNAPII-S5P ChIP e4C to identify spatial interactomes of mouse globin genes, using alpha and beta globin genes as baits
RNAPII-S5P ChIP e4C was performed on mouse erythroid tissue, using the alpha and beta globin genes as baits
ORGANISM(S): Mus musculus 
2009-12-01 | E-TABM-822 | biostudies-arrayexpress
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
GenomicsThe histone chaperone CAF-1 safeguards somatic cell identity during transcription factor-induced reprogramming (sequencing)
During development, specialized cell lineages are generated through the establishment of cell type-specific transcriptional patterns and epigenetic programs. However, the precise mechanisms and regulators that maintain these specialized cell states remain largely elusive. To identify molecules that ...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-72744 | biostudies-arrayexpress
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