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UnknownTargeted androgen pathway suppression in localized prostate cancer: a pilot study.
Not available
S-EPMC3887479 | biostudies-literature
TranscriptomicsTranscription profiling of mouse Dll3 and Notch1 homozygous mutant embryos to investigate craniofacial malformations of human birth defects
Mutations in the Notch1 receptor and delta-like 3 (Dll3) ligand cause global disruptions in axial segmental patterning. Genetic interactions between members of the notch pathway have previously been shown to cause patterning defects not observed in single gene disruptions. We examined Dll3-Notch1 ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-8027 | biostudies-arrayexpress
GenomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma [ChIP-seq]
In neuroblastoma, amplification of the oncogenic basic helix-loop-helix (bHLH) transcription factor (TF) MYCN is the defining prognosticator of high-risk disease, occurs in one-third of neuroblastoma, and drastically reduces overall survival rates. As a proto-oncogene, targeted MYCN overexpression i...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-80151 | biostudies-arrayexpress
TranscriptomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma [ATAC-seq]
In neuroblastoma, amplification of the oncogenic basic helix-loop-helix (bHLH) transcription factor (TF) MYCN is the defining prognosticator of high-risk disease, occurs in one-third of neuroblastoma, and drastically reduces overall survival rates1,2. As a proto-oncogene, targeted MYCN overexpressio...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-80152 | biostudies-arrayexpress
GenomicsPRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age related clonal hematopoiesis and myeloid neoplasia
Whole exome sequencing of 5 MDS/MPN patients to identify the target of chromosome 22 acquired uniparental disomy (22aUPD). For samples E4051 and E6523, peripheral blood leucocytes (tumour) and cultured T-cells (germline) were prepared for exome sequencing using the Agilent SureSelect kit (Agilent Te...
ORGANISM(S): Homo sapiens 
2019-01-22 | E-MTAB-7491 | biostudies-arrayexpress
TranscriptomicsDifferentially regulated genes in control and c-myc N-myc deficient LT-HSCs
Analysis of HSCs from control and c-myc N-myc deficient long-term hematopoietic stem cells. HSCs lacking both c-myc and N-myc display increased apoptosis rates. Data provide insight into the molecular changes occuring upon complete loss of Myc activity, clarifying the resulting apoptotic mechanism a...
ORGANISM(S): Mus musculus 
2009-02-20 | E-GEOD-12467 | biostudies-arrayexpress
UnknownAwareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairment.
Not available
S-EPMC3214821 | biostudies-literature
TranscriptomicsBiochemical Identification of Targets of Individual MicroRNAs in Mouse Embryonic Stem Cells
Mouse Embryonic Stem (ES) cells express a unique set of microRNAs (miRNAs), the miR-290-295 cluster. To elucidate the role of these miRNAs and how they integrate into the ES cell regulatory network requires identification of their direct regulatory targets. The difficulty, however, arises from the l...
ORGANISM(S): Mus musculus 
2010-02-27 | E-GEOD-20199 | biostudies-arrayexpress
UnknownMulti-omics profiling reveals PLEKHA6 as a modulator of β-catenin signaling and therapeutic vulnerability in lung adenocarcinoma
Not available
S-EPMC12344168 | biostudies-literature
ProteomicsYPIC challenge 2018: A case study in characterizing an unknown protein sample
For the YPIC challenge 2018 contestants were invited to try to decipher two unknown English questions encoded by a synthetic protein expressed in E. coli. We present how we analyzed this unknown sample using a tryptic digest with dynamic exclusion disabled to increase the signal-to-noise ratio of t...
ORGANISM(S): Escherichia coli 
2019-06-11 | PXD014003 | Pride
Spectral clustering Spectral networking Ypic De novo Synthetic protein 
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