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TranscriptomicsGlobal changes in the nuclear positioning of chromatin domains and genomic interactions that orchestrate B cell fate
The genome is folded into domains that are located in either transcriptionally inert or permissive compartments. Here we used genome-wide strategies to characterize domains during B cell development. Structured Interaction Matrix Analysis revealed that CTCF occupancy was primarily associated with i...
ORGANISM(S): Mus musculus 
2012-10-09 | E-GEOD-40173 | biostudies-arrayexpress
UnknownCompositions of gut microbiota before and shortly after hepatitis C viral eradication by direct antiviral agents.
Not available
S-EPMC8971444 | biostudies-literature
GenomicsOpposing roles of E2A and Id3 that orchestrate and enforce the naive T cell fate
It is established that E2A and its antagonist, Id3, modulate developmental progression at the pre-TCR and TCR checkpoints. Here we show at a global scale how E2A promotes commitment to the T cell lineage and how pre-TCR mediated signalling affects E2A genome-wide occupancy. We find aberrant develo...
ORGANISM(S): Mus musculus 
2011-07-31 | E-GEOD-30518 | biostudies-arrayexpress
GenomicsEstablishment of Enhancer Repertoires that Orchestrate the Myeloid and Lymphoid Cell Fates (ChIP-Seq dataset)
Recent studies have documented genome-wide binding patterns of transcriptional regulators and their associated epigenetic marks in hematopoietic cell lineages. In order to determine how epigenetic marks are established and maintained during developmental progression, we have generated long-term cult...
ORGANISM(S): Mus musculus 
2011-09-01 | E-GEOD-30858 | biostudies-arrayexpress
TranscriptomicsSimple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21512 | biostudies-arrayexpress
UnknownLncRNA SNHG1 regulates neuroblastoma cell fate via interactions with HDAC1/2.
Not available
S-EPMC9492769 | biostudies-literature
UnknownSynergic Effect of Early Administration of Probiotics and Adipose-Derived Mesenchymal Stem Cells on Alleviating Inflammation-Induced Chronic Neuropathic Pain in Rodents.
Not available
S-EPMC9570240 | biostudies-literature
UnknownmiR-122 Exerts Inhibitory Effects on Osteoblast Proliferation/Differentiation in Osteoporosis by Activating the PCP4-Mediated JNK Pathway.
Not available
S-EPMC7082497 | biostudies-literature
TranscriptomicsA global network of transcription factors, involving E2A, EBF1 and FOXO1, that orchestrates the B cell fate
It is now established that the transcription factors E2A, EBF1 and FoxoM-BM- 1 play critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1 as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis...
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-21978 | biostudies-arrayexpress
UnknownA HANC Risk Stratification Score for Antiplatelet Therapy Optimization with Low-Dose Prasugrel in Taiwanese Acute Coronary Syndrome Patients from the Switch Study.
Not available
S-EPMC9692225 | biostudies-literature
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