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ProteomicsProteomic changes to immune and inflammatory processes underlie lung preservation using ex vivo cytokine adsorption
The field of graft preservation has made considerable strides in recent years improving outcomes related to solid organ restoration and regeneration. In lungs, the use of ex vivo lung perfusion (EVLP) in line with devices and treatments has shown promising results within preclinical and clinical stu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-10-24 | PXD044413 | Pride
Evlp Lung transplantation Cytokine adsorption 
ProteomicsProteomic characteristics and diagnostic potential of exhaled breath particles in patients with COVID-19
Background SARS-CoV-2 has been shown to predominantly infect the airways and the respiratory tract and too often have an unpredictable and different pathologic pattern compared to other respiratory diseases. Current clinical diagnostical tools in pulmonary medicine expose patients to harmful radiati...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039058 | Pride
Human Exhaled breath particles Lung Covid-19 
ProteomicsUnraveling molecular and functional responses across three lung injury models to expand the donor lung pool
Background: Lung transplantation remains hampered by a scarcity of viable donor lungs, partially attributed to donor lung injuries. Methods: Three porcine lung injury models were studied: infection-induced using lipopolysaccharide (LPS) (n=7), aspiration-induced using endotracheal gastric content (n...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-06-30 | PXD054562 | Pride
Lung transplantation Ebp Lc-msms 
ProteomicsProteomic analysis of primary graft dysfunction and high particle flow rate
Background: Primary graft dysfunction (PGD) remains a challenge to lung transplantation (LTx) recipients as a leading cause of poor early outcomes. New methods are needed for the rapid detection of PGD and the measurement of particle flow rate (PFR) from exhaled breath is a novel means to monitor di...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-04-05 | PXD046365 | Pride
Primary graft dysfunction Lung transplantation Non-invasive monitoring Exhaled breath particles 
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