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MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
ProteomicsRole of Specialized Composition of SWI/SNF Complexes in Prostate Cancer Lineage Plasticity
Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance seen in 10% of these patients is through lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine pros...
ORGANISM(S): Homo sapiens (Human) 
2020-11-04 | PXD016861 | Pride
Swi/snf complex Lineage plasticity Prostate cancer Epigenetic 
ProteomicsONECUT2 acts a lineage plasticity driver
Androgen receptor- (AR-) indifference is a mechanism of resistance to hormonal therapy in prostate cancer (PC). Here we demonstrate that ONECUT2 (OC2) activates resistance through multiple drivers associated with adenocarcinoma, stem-like and neuroendocrine (NE) variants. Direct OC2 gene targets inc...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050634 | Pride
Onecut2 Prostate cancer Interactome Lc-ms/ms 
GenomicsBarcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1ER_F12_clone_2]
Barcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1ER_F12_clone_2]
PRJNA926522 | ENA
GenomicsBarcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1ER_F12_clone_3]
Barcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1ER_F12_clone_3]
PRJNA926560 | ENA
GenomicsBarcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [Barcode_decay_in_bulk_HA1ER]
Barcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [Barcode_decay_in_bulk_HA1ER]
PRJNA926565 | ENA
GenomicsBarcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1E_E7_clone]
Barcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1E_E7_clone]
PRJNA926563 | ENA
GenomicsBarcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1ER_F12_clone_1]
Barcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1ER_F12_clone_1]
PRJNA926524 | ENA
GenomicsBarcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1ER_F12_clone_TRAIL]
Barcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1ER_F12_clone_TRAIL]
PRJNA926558 | ENA
GenomicsBarcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1E_E7_clone_RAS]
Barcode decay Lineage Tracing, BdLT-Seq, unravels lineage-linked transcriptome plasticity [scRNAseq_BdLTseq_HA1E_E7_clone_RAS]
PRJNA926562 | ENA
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