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ProteomicsSystematic identification of cell fate regulatory programs using a single-cell atlas of mouse development
Single-cell genomics is altering our understanding of the Waddington landscape, and provides a more general representation of the state manifold. Yet, the molecular regulations behind the state manifold remain poorly understood. We construct a dynamic cell landscape of mouse lineage differentiation ...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-08 | PXD032847 | Pride
Lineage-common regulator  cell fate decision  cross species 
TranscriptomicsInnate lymphoid cell development requires TOX-dependent generation of a common ILC progenitor
Subtypes of innate lymphoid cells (ILC), defined by effector function and transcription factor expression, have recently been identified. In the adult, ILC derive from common lymphoid progenitors in bone marrow, although transcriptional regulation of the developmental pathways involved remains po...
ORGANISM(S): Mus musculus 
2015-04-27 | E-GEOD-65850 | biostudies-arrayexpress
TranscriptomicsPruning of the adipocyte cistrome by hematopoietic master regulator PU.1 (expression)
Master transcription factors are the gatekeepers of lineage identity. As such, they have been a major focus of efforts to manipulate cell fate for therapeutic purposes. The ETS transcription factor PU.1 has a potent ability to confer macrophage phenotypes on cells already committed to a different li...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48344 | biostudies-arrayexpress
GenomicsPruning of the adipocyte cistrome by hematopoietic master regulator PU.1 (ChIP-seq)
"Master" transcription factors are the gatekeepers of lineage identity. As such, they have been a major focus of efforts to manipulate cell fate for therapeutic purposes. The ETS transcription factor PU.1 has a potent ability to confer macrophage phenotypes on cells already committed to a ...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48343 | biostudies-arrayexpress
TranscriptomicsDysregulated TLR7 signaling drives anemia via development of hemophagocytic macrophages
The debilitating autoimmune disease Systemic Lupus Erythematosus (SLE) is closely associated with Toll-like receptor (TLR) 7 and type I interferon (IFN) activity in humans and in murine SLE-like disease. Two central manifestations of SLE affect the myeloid lineage of the immune system, myeloid expan...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-70520 | biostudies-arrayexpress
TranscriptomicsSimple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21512 | biostudies-arrayexpress
TranscriptomicsPruning of the adipocyte cistrome by hematopoietic master regulator PU.1 (expression)
Master transcription factors are the gatekeepers of lineage identity. As such, they have been a major focus of efforts to manipulate cell fate for therapeutic purposes. The ETS transcription factor PU.1 has a potent ability to confer macrophage phenotypes on cells already committed to a different li...
ORGANISM(S): Mus musculus 
2013-06-27 | GSE48344 | GEO
GenomicsMETTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [ChIPseq]
METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [ChIPseq]
PRJNA1013106 | ENA
GenomicsMETTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [DNAme]
METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [DNAme]
PRJNA1016410 | ENA
GenomicsMETTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [scRNAseq]
METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [scRNAseq]
PRJNA1015630 | ENA
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