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TranscriptomicsWhole Genome sequencing of a normal karyotype AML cell line
Normal Karyotype acute myeloid leukemia (NK-AML) represents approximately 50% of all cases of AML which patients develop. Most AML cell lines are highly abnormal and therefore not good models for investigating NK-AML biology a novel AML cell line, CG-SH, was recently estabished and here we characte...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-40199 | biostudies-arrayexpress
TranscriptomicsThe APSES Transcription factor Efg1 regulates a novel phenotype switch in Candida parapsilosis [RNA-seq].
In Candida albicans the Efg1 transcription factor (a member of the APSES family) is an important regulator of hyphal growth, and of the white-to-opaque transition. In contrast, we show that the Efg1 ortholog in Candida parapsilosis is a major regulator of a different morphological switch at the colo...
ORGANISM(S): Candida parapsilosis 
2013-06-20 | E-GEOD-41064 | biostudies-arrayexpress
GenomicsThe APSES Transcription factor Efg1 regulates a novel phenotype switch in Candida parapsilosis [ChIP-seq].
We use ChIP-seq to identify the targets of Efg1 in Candida parapsilosis. We show that Efg1 binds to 502 promoter regions, including 70 potential transcription factors or regulatory proteins. Several of the transcription factors belong to networks that regulate biofilm development and white-opaque sw...
ORGANISM(S): Candida parapsilosis 
2013-06-20 | E-GEOD-41063 | biostudies-arrayexpress
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