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ProteomicsImpact of Alanyl-tRNA Synthetase Editing Deficiency in Yeast
Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that provide the ribosome with aminoacyl-tRNA substrates for protein synthesis. Mutations in aaRSs lead to various neurological disorders in humans. Many aaRSs utilize editing to prevent error propagation during translation. Editing defects in...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-26 | PXD026930 | Pride
Label-free quantitative proteomics Yeast alars variants 
ProteomicsSaccharomyces cerevisiae translational fidelity
Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that ligate amino acids to tRNAs, and often require editing to ensure accurate protein synthesis. Recessive mutations in aaRSs cause various neurological disorders in humans, yet the underlying mechanism remains poorly understood. Pathogenic a...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-01-26 | PXD042145 | Pride
Mistranslation Aminoacyl-trna synthetase Protein synthesis 
GenomicsNational Human Genome Research Institute Tumor Sequencing Project (TSP) - Lung Adenocarcinoma

The Tumor Sequencing Project (TSP) Consortium is a collaboration among participants at the Baylor College of Medicine Human Genome Sequencing Center, the Broad Institute Genome Sequencing Platform, the Dana Farber Cancer Institute, the Memorial Sloan-Kettering Cancer Center, the Genome Seque...

phs000144.v1.p1 | EGA
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