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Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
Transfer RNAs (tRNAs) maintain translational fidelity through strict charging by their cognate aminoacyl-tRNA synthetase and codon:anticodon base pairing with the mRNA at the ribosome. Mistranslation occurs when an amino acid not specified by the genetic code is incorporated into a protein. Since al...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-10-02 | PXD038242 | Pride
Mistranslation, the mis-incorporation of an amino acid not specified by the “standard” genetic code, occurs in all cells. tRNA variants that increase mistranslation arise spontaneously and engineered tRNAs can achieve mistranslation frequencies approaching 10% in yeast and bacteria. The goal of this...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-12 | PXD032063 | Pride
Mistranslation, the mis-incorporation of an amino acid not specified by the “standard” genetic code, occurs in all cells. tRNA variants that increase mistranslation arise spontaneously and engineered tRNAs can achieve mistranslation frequencies approaching 10% in yeast and bacteria. The goal of this...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-05-17 | PXD025934 | Pride
Global and specific mechanisms stimulate mistranslation in cancer
Global and specific mechanisms stimulate mistranslation in cancer - tRNA sequences
Evolution of robustness to protein mistranslation by accelerated protein turnover
Global and specific mechanisms stimulate mistranslation in cancer
Transcriptome analysis in cells after 20 hours of mistranslation induction in relation to control cells at the same time point where mistranslation was not induced (without the inducible tRNA construction)
ORGANISM(S): Saccharomyces cerevisiae 
Global and specific mechanisms stimulate mistranslation in cancer
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