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GenomicsImpacts of the Ubiquitous Factor Zelda on Bicoid-dependent DNA-binding and Transcription in Drosophila
In vivo crosslinking studies suggest that the Drosophila transcription factor Bicoid (Bcd) binds to several thousand sites during early embryogenesis, but it is not clear how many of these binding events are functionally important. In contrast, reporter gene studies have identified more than 60 Bcd-...
ORGANISM(S): Drosophila melanogaster 
2014-05-02 | E-GEOD-55256 | biostudies-arrayexpress
TranscriptomicsGene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice
Constitutive Kras and NF-kappaB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms of constitutive NF-kappaB activation in KrasG12D-induced PDAC are not yet understood. Here, we report that pancreas-targeted IKK2/beta inactivat...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-27478 | biostudies-arrayexpress
ProteomicsAstrocyte and neuron cell surface proteomes
We developed, tested and validated a method to determine the cell surface proteomes (CSPs) of striatal astrocytes and neurons. We used this method to study the CSPs and how they change in mouse models of disorders that affect the striatum. We compared our data to postmortem human data to identify di...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-20 | MSV000094132 | MassIVE
ProteomicsComprehensive genome editing and signaling pathway engineering evolve potent and safe adenoviral producer cell
Dramatic attention has been drawn to adenovirus as a vehicle for vaccine and cancer therapy, due to the capabilities of annihilating tumor cells and stimulating host immune response. However, few producer cells are perfect for adenoviral manufacture. Herein, a novel genome editing strategy by CRISPR...
ORGANISM(S): Homo Sapiens 
2025-10-21 | PXD069719 |
ProteomicsDirect Evolution of Adeno-Associated Virus 5 Capsid Enables Specific Liver Tropism
Gene therapy has been thriving in recent years, as featured by general triumphs in several clinical trials to treat hemophilia. It highlights the significance of AAV mediated gene delivery to liver. AAV5 is a unique serotype with low neutralizing antibody prevalence. In this study, we generated an A...
ORGANISM(S): Adeno-associated Virus - 5 
2022-04-01 | PXD032891 |
UnknownImmunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database.
Not available
S-EPMC5998562 | biostudies-literature
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