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TranscriptomicsInsulin-like Signaling Determines Survival During Stress via Post Transcriptional Mechanisms in C. elegans.
The insulin-like signaling (ILS) pathway regulates metabolism and is known to modulate adult lifespan in C. elegans. Altered stress responses and resistance to a wide range of stressors are also associated with changes in ILS and contribute to enhanced longevity. The transcription factors DAF-16 and...
ORGANISM(S): Caenorhabditis elegans 
2010-06-17 | E-GEOD-22383 | biostudies-arrayexpress
TranscriptomicsCXCL12 Production by Early Mesenchymal Progenitors is Required for Hematopoietic Stem Cell Maintenance
Hematopoietic stem cells (HSCs) primarily reside in the bone marrow where signals generated by stromal cells regulate their self-renewal, proliferation, and trafficking. Endosteal osteoblasts and perivascular stromal cells including endothelial cells3, CXCL12-abundant reticular (CAR) cells, leptin-...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43613 | biostudies-arrayexpress
TranscriptomicsHematopoietic stem cells from mice treated with G-CSF or saline alone for 36 hours
Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells (HSCs). Granulocyte-colony stimulating factor (G-CSF) is often induced with infection and plays a key role in the stress granulopoiesis response. However, its effects on HSCs are less clear. Herein, we show tha...
ORGANISM(S): Mus musculus 
2014-02-19 | E-GEOD-55093 | biostudies-arrayexpress
GenomicsHeat Shock in C. elegans Induces Downstream of Gene Transcription and Accumulation of Double-Stranded RNA
Heat Shock in C. elegans Induces Downstream of Gene Transcription and Accumulation of Double-Stranded RNA
PRJNA495081 | ENA
TranscriptomicsGlobal changes in the nuclear positioning of chromatin domains and genomic interactions that orchestrate B cell fate
The genome is folded into domains that are located in either transcriptionally inert or permissive compartments. Here we used genome-wide strategies to characterize domains during B cell development. Structured Interaction Matrix Analysis revealed that CTCF occupancy was primarily associated with i...
ORGANISM(S): Mus musculus 
2012-10-09 | E-GEOD-40173 | biostudies-arrayexpress
GenomicsTDP-1, the C. elegans ortholog of TDP-43, limits the accumulation of double stranded RNA
C. elegans mutants deleted for TDP-1, an ortholog of the neurodegeneration-associated RNA binding protein TDP-43, display only mild phenotypes. Nevertheless, transcriptome sequencing revealed that many RNAs were altered in accumulation and/or processing in the mutant. Analysis of these transcription...
ORGANISM(S): Caenorhabditis elegans 
2014-11-19 | E-GEOD-61581 | biostudies-arrayexpress
ProteomicsChapman_CCM_2018
This submission contains the mass spectrometry files for the manuscript by Chapman and colleagues that characterize KRI-1 in C. elegans by affinity purification experiments of KRI-1 fused to GFP. Controls used for this experiment include ACT-5 fused to GFP and N2 worms. This dataset consists of 18 ...
ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239) 
2018-05-24 | MSV000082400 | MassIVE
TranscriptomicsTMPRSS2 Influences Prostate Cancer Metastasis
TMPRSS2 is an androgen-regulated cell surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastasis. Through the generation of mouse models with a targeted deletion ...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-58822 | biostudies-arrayexpress
UnknownEarly Relapse of Follicular Lymphoma After Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Defines Patients at High Risk for Death: An Analysis From the National LymphoCare Study.
Not available
S-EPMC4879714 | biostudies-literature
GenomicsSRA/SET domain-containing proteins link RNA polymerase V occupancy to DNA methylation
RNA-directed DNA methylation (RdDM) in Arabidopsis thaliana depends on the synthesis of non-coding RNAs by nuclear RNA polymerase E (NRPE or Pol V) 1-3, but the mechanism by which Pol V is targeted is unknown. Here we show that genome-wide Pol V association with chromatin redundantly requires the ...
ORGANISM(S): Arabidopsis thaliana 
2014-01-01 | E-GEOD-52041 | biostudies-arrayexpress
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