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MetabolomicsHomeostasis of the biosynthetic E. coli metabolome
Metabolite concentrations vary across conditions and such metabolome changes are relevant for metabolic and gene regulation. Here, we used LC-MS/MS to explore metabolite concentration changes in Escherichia coli. We measured 101 primary metabolites in 19 experimental conditions that include v...
2022-11-02 | MTBLS4249 | MetaboLights
MetabolomicsSystematic identification of metabolites controlling gene expression in E. coli
Metabolism controls gene expression through allosteric interactions between metabolites and transcription factors. These interactions are usually measured with in vitro assays, but there are no methods to identify them at a genome-scale in vivo. Here we show that dynamic transcriptome and metabolome...
2019-08-23 | MTBLS1044 | MetaboLights
MetabolomicsHorizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness

Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous diversity of compounds, and the corresponding BGCs are frequen...

2022-11-09 | MTBLS5196 | MetaboLights
ModelsSlaviero2021 - E. coli anaerobic central carbon and energy metabolism_Version1
This model describes the central carbon and energy metabolism of E. coli growing under anaerobic conditions. For complete information about the model see: 'Deciphering the physiological response of Escherichia coli under high ATP demand Simon Boecker, Giulia Slaviero, Thorben Schramm, Witold Szyman...
2022-02-13 | MODEL2202020001 | BioModels
TranscriptomicsThe ETHYLENE RESPONSE FACTOR 6 Acts as a Central Regulator of Leaf Growth under Water-Limiting Conditions in Arabidopsis thaliana
Leaf growth is a complex developmental process that is continuously fine-tuned by the environment. Various abiotic stresses, including mild drought stress, have been shown to inhibit leaf growth in Arabidopsis thaliana (Arabidopsis), but the underlying mechanisms remain largely unknown. Here we iden...
ORGANISM(S): Arabidopsis thaliana 
2013-04-06 | E-GEOD-45830 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of hemagglutinin specific B cells after influenza virus infection: gene expression data
Understanding dynamics of antigen specific B cell responses and link between BCR and B cell differentiation is crucial for our ability to direct immune responses and to generate memory and plasma cells responses to protective targets. Here we have infected mice with IAV-PR8 and sacrificed them at di...
ORGANISM(S): Mus musculus 
2021-06-22 | E-MTAB-9491 | biostudies-arrayexpress
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