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ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD033533 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD033381 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsSuper-SILAC reveals intricate crosstalk between lipopolysaccharide, phospholipid and fatty acid metabolism in Escherichia coli
The only membrane-anchored and essential ATP-dependent protease in Escherichia coli is FtsH. It controls the intracellular concentration of the deacetylase LpxC, which catalyses the first committed step in lipopolysaccharide biosynthesis. LpxC stability is strictly regulated in a growth rate-depende...
ORGANISM(S): Escherichia coli 
2019-11-12 | PXD006195 | Pride
Lipopolysaccharide Lc-ms/ms Escherichia coli Ftsh Lpxc Proteolysis Super-silac Quantitative proteomics 
TranscriptomicsIntrathymic origins of T-ALL
Leukemia cells are considered developmentally 'frozen', and their phenotype is thought to reflect their stage of origin. To gain insights into the cell population from which T-ALL arises, we compared by global gene expression profiling T-ALL samples (n = 10) to different stages of T cell development...
ORGANISM(S): Mus musculus 
2014-05-16 | E-GEOD-56416 | biostudies-arrayexpress
GenomicsBlueprint Data Access Committee
Access to the sequence and alignment and genotype level data produced by the Blueprint Consortium is controlled by the Blueprint Data Access Committee (DAC). Access to data will be granted to qualified investigators for appropriate use. Please follow the link http://www.blueprint-epigenome.eu/index....
EGAC00001000135 | EGA
ProteomicsProtein S-nitrosylation in lung endothelial cells from mouse
Long.term consequences of loss of arginase-1 (Arg1) in red blood cells were analysed by redox-proteomics. We enriched S-Nitrosylated proteins to study nitrosylated proteins in red-bood cells using a BIAM-switch assay.
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD075167 | Pride
S-nitrosylation Redox-proteomics 
ProteomicsProteome of senescent human lung fibroblasts and Panc-1 cells
Proteomic analysis of proliferating and senescent normal healthy lung fibroblasts (NHLFs) and Panc-1 cells. Senescence was induced using 5 uM Palbociclib for 6 days. Cells were lysed in SDS lysis buffer (2% SDS in 100 mM TEAB), boiled (15 min, 95 °C, 500 rpm) and sonicated in a sonication bath (10 ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-28 | MSV000090607 | MassIVE
TranscriptomicsNucleosome maps of the human cytomegalovirus genome reveal a temporal switch in chromatin organization linked to a major IE protein
Human CMV (hCMV) establishes lifelong infections in most of us, causing developmental defects in human embryos and life-threatening disease in immunocompromised individuals. During productive infection, the viral >230,000-bp dsDNA genome is expressed widely and in a temporal cascade. The hCMV genome...
ORGANISM(S): Human Herpesvirus 5 
2013-07-17 | E-GEOD-48875 | biostudies-arrayexpress
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