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ProteomicsSuper-SILAC reveals intricate crosstalk between lipopolysaccharide, phospholipid and fatty acid metabolism in Escherichia coli
The only membrane-anchored and essential ATP-dependent protease in Escherichia coli is FtsH. It controls the intracellular concentration of the deacetylase LpxC, which catalyses the first committed step in lipopolysaccharide biosynthesis. LpxC stability is strictly regulated in a growth rate-depende...
ORGANISM(S): Escherichia coli 
2019-11-12 | PXD006195 | Pride
Lipopolysaccharide Lc-ms/ms Escherichia coli Ftsh Lpxc Proteolysis Super-silac Quantitative proteomics 
ProteomicsSame same but different – The global response of Escherichia coli to five different LpxC inhibitors
A promising but yet clinically unexploited antibiotic target in difficult-to-treat Gram-negative bacteria is LpxC, the key enzyme in the biosynthesis of lipopolysaccharides (LPS), which are the major constituents of the outer membrane. To gain insights into the mode of action of five different LpxC ...
ORGANISM(S): Escherichia coli 
2024-06-16 | PXD043195 | Pride
Lipopolysaccharide Lps Antibiotics Phospholipid Outer membrane Ftsh 
GenomicsEffects of LpxC and lpxD disruption on Acinetobacter baumannii and phage interactions
Effects of LpxC and lpxD disruption on Acinetobacter baumannii and phage interactions
PRJNA1289028 | ENA
TranscriptomicsEffects of LpxC and lpxD disruption on Acinetobacter baumannii and phage interactions
LpxC and lpxD are involved in the synthesis of bacterial LPS and are essential for the maintenance of bacterial outer membrane integrity.Here, we show that loss of lpxC and lpxD affects energy metabolism in A. baumannii and is associated with bacterial-phage interactions.The lpxC and lpxD deficient ...
ORGANISM(S): Acinetobacter baumannii Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841 
2025-07-31 | GSE302131 | GEO
UnknownAntibacterial Drug Discovery Targeting the Lipopolysaccharide Biosynthetic Enzyme LpxC.
Not available
S-EPMC4930914 | biostudies-literature
UnknownSynthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors.
Not available
S-EPMC3941642 | biostudies-literature
UnknownInterplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis.
Not available
S-EPMC6211225 | biostudies-literature
UnknownSpecies-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
Not available
S-EPMC3149848 | biostudies-literature
UnknownSynthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.
Not available
S-EPMC4233352 | biostudies-literature
UnknownMechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.
Not available
S-EPMC3022321 | biostudies-literature
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