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TranscriptomicsTranscription profiling of liver from PPARalpha knockout mice: PPARa -dependent regulation of hepatic lipid metabolism by expression profiling (GEO Super series)
This SuperSeries is composed of the following subset Series:; GSE8290: Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 1; GSE8291: Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 2...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8316 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 3-5 months old males wild-type (129S1/SvImJ) and PPARalpha-null (129S4/SvJae) to investigate PPARalpha-dependent regulation of hepatic lipid metabolism - 4
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8295 | biostudies-arrayexpress
MetabolomicsInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of membrane tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. In contrast, we reveal here a funct...
2021-05-06 | MTBLS2444 | MetaboLights
MetabolomicsRole of breast milk lipid composition in postnatal brain development.

Lipids in the brain play a crucial role as structural and signaling molecules, accounting for approximately 60% of the brain’s dry weight. Several lipid classes exhibit concentration profile differences between humans and other species, including closely related primates, with the most pronounced...

2025-09-25 | MTBLS12481 | MetaboLights
TranscriptomicsTranscription profiling of rat livers with inactivated PPARI
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8302 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from wild-type (129S1/SvImJ) and PPARalpha-null (129S4/SvJae) animals treated with WY14643 vs. controls - 3
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8292 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild-type and PPARI?-null liver treated with the synthetic PPARI? ligand WY14643
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8291 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver wild type and PPARI?-nulls -1
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8290 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of human macrophages exposed to lipoprotein lipase hydrolysis products
Lipoprotein lipase (LPL) is an extracellular lipase that preferentially hydrolyses triglycerides in triglyceride-rich lipoproteins within the circulation. LPL expression in macrophages contributes to atherosclerosis. In addition, the hydrolysis products liberated from lipoprotein lipids by LPL cause...
ORGANISM(S): Homo sapiens 
2017-02-15 | GSE84791 | GEO
MetabolomicsWhat CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines

Background: Cell line specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such models have recently become available for Chinese hamster ovary (CHO) too. However, a key ingredient, namely an experimentally validat...

2020-07-13 | MTBLS1210 | MetaboLights
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