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MetabolomicsDual metal electrolysis in theta capillary for lipid analysis

Increasing studies associating glycerophospholipids with various pathological conditions highlight the need for their thorough characterization. However, the intricate composition of the lipidome due to the presence of lipid isomers poses significant challenges to structural lipidomics. This stud...

2023-10-10 | MTBLS8547 | MetaboLights
MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
MetabolomicsThe lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in colorectal cancer (CRC) evolution has not been repo...
2024-10-01 | MTBLS10323 | MetaboLights
MetabolomicsOxygen-induced pathological angiogenesis promotes intense lipid synthesis and remodeling in the retina

The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural retina while maintaining constant supplies of oxygen, nutrients and dietary essential fatty acids. Here we analyzed the lipidome of the mouse retina under healthy and patho...

2023-05-09 | MTBLS6965 | MetaboLights
MetabolomicsComprehensive Analysis of Differences in Cashmere Production Performance in Liaoning Cashmere Goats by Using Metabolomics and Transcriptomics

This study integrated transcriptomics and metabolomics to analyse the molecular differences in the skin tissues of perennial long wool type (PT-LCG) and seasonal long wool type (ST-LCG) Liaoning cashmere goats to reveal the regulatory mechanisms underlying their differences in cashmere production...

2025-11-27 | MTBLS13406 | MetaboLights
MetabolomicsProduction of new microbially conjugated bile acids by human gut microbiota

Gut microbes have been recognized to convert the human bile acids by deconjugation, dehydroxylation, dehydrogenation and epimerization of the cholesterol core, but the ability to re-conjugate them with amino acids as an additional conversion has only been recently described. These new bile acids ...

2024-01-16 | MTBLS4140 | MetaboLights
MetabolomicsQuantitative trait loci analysis identifies a prominent gene involved in the production of fatty-acid-derived flavor volatiles in tomato
To gain insight into the genetic regulation of lipid metabolism in tomato, we conducted metabolic trait loci (mQTL) analysis following the lipidomic profiling of fruit pericarp and leaf tissue of the Solanum pennellii introgression lines. To enhance mapping resolution for selected fruit-specific mQT...
2018-07-16 | MTBLS693 | MetaboLights
MetabolomicsAnalysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis
Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only are gametocytes able to survive in radically different host environments, but they are also precursors for male and female g...
2022-04-05 | MTBLS4137 | MetaboLights
MetabolomicsB cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size.

The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states...

2026-04-13 | MTBLS13880 | MetaboLights
MetabolomicsAnalysis of flavor formation and metabolite changes during production of buffalo milk Double-Layer Steamed Milk Custard

Metabolomics analysis showed that concentration of free amino acids and short-chain fatty acid lipids were increased in DLSMC, and they were more easily digested and absorbed. Key metabolic pathways, including alanine, aspartate, and glutamate metabolism, starch and sucrose metabolism, and glycer...

2025-08-23 | MTBLS12717 | MetaboLights
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