Sort   by:  
 Page size 
MetabolomicsMetabolic plasticity of lipid storage and utilization governs fungal persister formation within macrophages
The ability of Candida glabrata to survive within macrophages creates a reservoir for recurrent infections and antifungal failure, yet the underlying mechanisms remain elusive. Here, using a host-mimicking in vitro evolution model, we identify asparagine synthetase (ASN2) as a critical genetic deter...
2026-04-22 | MTBLS14351 | MetaboLights
MetabolomicsGlucagon-induced PGC-1aplha4/PPARgamma promotes hepatic lipid storage and macrosteatosis in fasting and MASLD

Please update the study abstract/descriptionThe liver plays a central role in regulating the transition between fasting and feeding states, coordinating glycogen breakdown, gluconeogenesis, fatty acid catabolism, and lipid storage. Disruptions in this balance contribute to metabolic disorders, in...

2026-06-16 | MTBLS13087 | MetaboLights
MetabolomicsDoes Storage Post Sampling Influence the Stability of Sebum when used for Mass Spectrometry Metabolomics Analysis?

Sebum is a biofluid excreted by sebaceous glands in the skin. In recent years sebum has been shown to contain endogenous metabolites diagnostic of disease, with remarkable results for Parkinson’s Disease. Given that sebum sampling is facile and non-invasive, its potential for use in clinical bioc...

2025-07-15 | MTBLS7946 | MetaboLights
MetabolomicsMetabolomics reveals stage-specific internal quality deterioration and distinct metabolic changes in egg albumen and yolk during storage

Internal quality of chicken eggs deteriorates during storage, but the biochemical changes occurring in albumen and yolk over storage time remain insufficiently characterized. This study investigated changes in internal quality traits and specific metabolite profiles in albumen and yolk of chicken...

2026-07-17 | MTBLS15068 | MetaboLights
MetabolomicsDifferential Metabolomic Biomarkers Analysis of Apheresis Platelet Storage Based on Machine Learning Models

Platelet storage lesion (PSL) is a critical factor limiting the efficacy of platelet transfusion. Although hypothermic (4°C) storage is considered beneficial for maintaining platelet function, the underlying mechanisms of systemic metabolic reprogramming remain incompletely understood. This study...

2026-07-27 | MTBLS15165 | MetaboLights
MetabolomicsAn obligate aerobe adapts to hypoxia by hybridising fermentation with carbon storage
In soil ecosystems, obligately aerobic bacteria survive oxygen deprivation (hypoxia) by entering non-replicative persistent states. Little is known about how these bacteria rewire their metabolism to stay viable during persistence. The model obligate aerobe Mycobacterium smegmatis maintains redox ho...
2026-04-22 | MTBLS11404 | MetaboLights
MetabolomicsHERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...
2025-04-03 | MTBLS5163 | MetaboLights
MetabolomicsLipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress
Liver steatosis can be induced by fasting or high-fat diet. We investigated by lipidomic analysis whether such metabolic states are reflected in the lipidome of hepatocyte lipid droplets (LDs) from mice fed normal chow diet (FED), fasted (FAS), or fed a high-fat diet (HFD). LC-MS/MS at levels of lip...
2014-08-19 | MTBLS26 | MetaboLights
MetabolomicsLipid Data Analyzer: Novel lipid species and identification of regio-isomeric lipid species (HCD characterization and regioisomer detection)
Lipid Data Analyzer (LDA; http://genome.tugraz.at/lda2) provides automated and reliable annotation of lipid species and their molecular structures in high-throughput data from chromatography-coupled tandem mass spectrometry using embedded rule sets. Using various low- and high-resolution mass spectr...
2017-11-07 | MTBLS462 | MetaboLights
MetabolomicsLipid Droplet Inhibitors for Disrupting Lipid Accumulation in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Excessive lipid droplet accumulation in hepatocytes drives the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), often leading to inflammation and fibrosis. As obesity and metabolic syndrome rise, MASLD has become a global concern, spurring research into effective trea...
2025-07-17 | MTBLS12359 | MetaboLights
Sort   by:  
 Page size