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ProteomicsLipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lysomitochondrial dysfunction, and lipid dyshomeostasis
Lipofuscin is an autofluorescent material that accrues in brain tissues with age and in Neuronal Ceroid Lipofuscinosis (NCL), a neurodegenerative disease with pediatric onset. The distribution, composition, and organellar origin of lipofuscin have remained unclear despite its widespread presence in ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-06 | PXD054766 | Pride
Genomics
Lipofuscin treatment to human keratinocytes
PRJNA945205 | ENA
UnknownLipofuscin Granule Accumulation Requires Autophagy Activation.
Not available
S-EPMC10440269 | biostudies-literature
GenomicsTranscription profiles of mouse microglia isolated by FACS from WT and Grn KO animals, separated by lipofuscin levels [hex001110]
Transcription profiles of mouse microglia isolated by FACS from WT and Grn KO animals, separated by lipofuscin levels [hex001110]
PRJNA1453395 | ENA
UnknownLipofuscin causes atypical necroptosis through lysosomal membrane permeabilization.
Not available
S-EPMC8617501 | biostudies-literature
UnknownMyocardial lipofuscin accumulation in ageing and sudden cardiac death.
Not available
S-EPMC6397159 | biostudies-literature
UnknownLipofuscin accumulates in ganglionic neurons in chronic equine dysautonomia.
Not available
S-EPMC11529066 | biostudies-literature
TranscriptomicsTranscription profiles of mouse microglia isolated by FACS from WT and Grn KO animals, separated by lipofuscin levels [hex001110]
Previous single-cell RNA sequencing of microglia from aged WT and Grn KO mice revealed a microglial subset with transcriptomic signatures that were highly specific to Grn KO. Immunohistochemistry analysis suggested that this population was also characterized by high lipofuscin burden. In this study,...
ORGANISM(S): Mus musculus 
2026-07-20 | GSE327960 | GEO
UnknownLipofuscin-associated photo-oxidative stress during fundus autofluorescence imaging.
Not available
S-EPMC5325292 | biostudies-literature
UnknownThe utilization of fluorescence to identify the components of lipofuscin by imaging mass spectrometry.
Not available
S-EPMC4017854 | biostudies-literature
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