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MetabolomicsOptimised LC-MS Metabolomic Profiling Reveals Emergent Changes to Monocyte Metabolism in Response to Lipopolysaccharide
Immunometabolism examines the links between immune cell function and metabolism. Dysregulation of immune cell metabolism is now an established feature of innate immune cell activation. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have allowed discovery of unique insights ...
2025-11-17 | MTBLS6730 | MetaboLights
MetabolomicsThe Lipopolysaccharide-Induced Metabolome Signature in Arabidopsis thaliana Reveals Dynamic Reprogramming of Phytoalexin and Phytoanticipin Pathways
Lipopolysaccharides (LPSs), as MAMP molecules, trigger the activation of signal transduction pathways involved in defence. Currently, plant metabolomics is providing new dimensions into understanding the intracellular adaptive responses to external stimuli. The effect of LPS on the metabolomes of Ar...
2017-05-03 | MTBLS272 | MetaboLights
TranscriptomicsLipopolysaccharide-stimulated neutrophils
Neutrophil gene transcription following lipopolysaccharide exposure. Microarray analysis of lipopolysaccharide-treated human neutrophils. Neutrophils respond to infection by degranulation, release of reactive oxygen intermediates, and secretion of chemokines and cytokines; however, activation of neu...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-105 | biostudies-arrayexpress
MetabolomicsIntravenous lipopolysaccharide infusion and the bovine metabolome
Not available
ORGANISM(S): Bos taurus 
ST002063 | MetabolomicsWorkbench
MetabolomicsNorbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFkB, MAPK and STAT3 activation and blocking metabolic reprogramming

Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine norbergenin, a constituent of traditional anti-inflammatory reci...

2023-04-06 | MTBLS7127 | MetaboLights
MetabolomicsBerberine improves intestinal barrier and cognitive impairment by remodeling intestinal microbiota in C57BL/6 septic mice induced by LPS
After feeding LPS induced C57BL/6 septic mice with berberine, we performed behavioral, HE staining, ELISA, western blot, metagenomic sequencing of gut microbiota and untargeted metabolomics analysis to evaluate the effects of berberine on septic mice.
2026-06-17 | MTBLS14775 | MetaboLights
TranscriptomicsmiRNA array for LPS-activated tnc+/+ and tnc-/- macrophages
Endogenous molecules generated upon pathogen invasion or tissue damage serve as danger signals that activate host defence, however their precise immunological role remains unclear. Tenascin-C is an extracellular matrix glycoprotein that is specifically induced upon injury and infection. We have show...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-41584 | biostudies-arrayexpress
ProteomicsStructure of an essential inner membrane protein-LPS complex identifies a novel anti-microbial peptide
Lipopolysaccharide (LPS) resides in the outer membrane (OM) of Gram-negative bacteria where it is responsible for barrier function and immune modulation. LPS is the target of polymyxins, last-resort antibiotics whose clinical use is threatened by increasing resistance. Steps in LPS biogenesis are ...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2019-05-08 | MSV000083754 | MassIVE
TranscriptomicsTranscriptional responses of mouse bone marrow-derived macrophages (BMM) to lipopolysaccharide (LPS) - Illumina arrays
These microarrays were performed for use in a genome-wide scan for LPS-regulated genes in mouse macrophages, in order to construct a list of LPS-regulated genes for detailed interrogation on custom microarrays (see GSE19490 for custom array analysis). Mouse macrophages (bone marrow-derived macrophag...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-19766 | biostudies-arrayexpress
TranscriptomicsData expression in alveolar macrophages induced by lipopolysaccharide in humans
Rationale: Lipopolysaccharide (LPS) is ubiquitous in the environment. Inhalation of LPS has been implicated in the pathogenesis and/or severity of several lung diseases, including pneumonia, chronic obstructive pulmonary disease and asthma. Alveolar macrophages are the main resident leukocytes expos...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-40885 | biostudies-arrayexpress
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