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MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
TranscriptomicsTranscription profiling of human T cells from patients presenting with AML compared with healthy T cells
Work previously published by our group has demonstrated that T cells from patients with chronic lymphocytic leukaemia (CLL) show differentially regulated genes compared with healthy T cells. This study was initiated to examine if these gene expression changes were unique to CLL T cells or common to ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-14924 | biostudies-arrayexpress
UnknownIn Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors.
Not available
S-EPMC5494305 | biostudies-literature
UnknownAML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia.
Not available
S-EPMC2883733 | biostudies-literature
UnknownPeripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts.
Not available
S-EPMC2773481 | biostudies-literature
ProteomicsHigh confidence glycosomal membrane protein inventory unveils trypanosomal Peroxin PEX15
Infections by trypanosomatid parasites cause Chagas disease, Human African Trypanosomiasis, and Leishmaniasis, affecting over 12 million people worldwide. Glycosomes, the unique peroxisome-related organelles of trypanosomes are essential for their survival, and hence their metabolic functions and bi...
ORGANISM(S): Trypanosoma brucei 
2025-10-23 | PXD057212 | Pride
Protein correlation profiling Trypanosoma brucei Glycosomal membrane proteome Tbpex15 
GenomicsGenome-wide methylome profiling of normal breast and breast tumors
To improve our understanding of the effect of differential methylation on gene expression between normal and tumor breast cells, we employed high-throughput sequencing technology to determine and compare CpG methylation of normal breast and four breast tumor genomes at single-base resolution. By com...
ORGANISM(S): Homo sapiens 
2015-02-25 | E-MTAB-2014 | biostudies-arrayexpress
GenomicsRecurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Follicular lymphoma (FL) is an incurable B-cell malignancy characterized by the t(14;18) and mutations in one or more components of the epigenome. Whilst frequent gene mutations in signaling pathways, including JAK-STAT, NOTCH and NF-κB, have also been defined, the spectrum of these mutations typic...
EGAS00001001190 | EGA
UnknownMicrodeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease.
Not available
S-EPMC2373322 | biostudies-literature
Genomicsena-DATASET-BCI-18-03-2015-12:48:54:303-380 - samples
Whole exome sequencing data of 5 patients diagnosed with FL that had undergone several relapse episodes without evidence of transformation
EGAD00001001301 | EGA
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