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TranscriptomicsTranscription profiling of hippocampal neuronal cell line HT-22 after 7 days of 3mM Lithium treatment
Effect of 3 mM lithium on gene's expression in mouse hippocampal neuronal cell line HT-22 after 7 days of treatment
ORGANISM(S): Mus musculus 
2006-02-01 | E-MEXP-521 | biostudies-arrayexpress
MetabolomicsEffects of MeJA on Arabidopsis metabolome under endogenous JA deficiency
Jasmonates (JAs) play important roles in plant growth, development and defense. Comprehensive metabolomics profiling of plants under JA treatment provides insights into the interaction and regulation network of plant hormones. Here we applied high resolution mass spectrometry based metabolomics appr...
2017-10-23 | MTBLS375 | MetaboLights
ProteomicsProteomic Profiling of the Hippocampus in Lithium-Deficient 3xTg-AD Mice
This proteomics experiment aimed to identify proteins whose abundance is altered by lithium deficiency in the context of Alzheimer's disease pathology in mice. Female homozygous 3xTg-AD mice were continuously fed either a lithium-deficient or a control diet from 6 to 15 months of age. At the end of ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD063039 | Pride
Hippocampus Alzheimer's disease Lithium Lithium deficiency 
GenomicsLithium Deficiency and the Onset of Alzheimer’s Disease
Lithium Deficiency and the Onset of Alzheimer’s Disease
PRJNA1136488 | ENA
MetabolomicsMetabolomics Analysis of the Effect of GAT-2 Deficiency on Th1 Cells in Mice

The classic neurotransmitter gamma-aminobutyric acid (GABA) has been shown to shape the activation and function of immune cells. There are four high affinity GABA transporters (GATs, including GAT-1, GAT-2, GAT-3 and GAT-4) responsible for the transmembrane transport of GABA in mice. To explore t...

2021-10-14 | MTBLS3358 | MetaboLights
GenomicsLithium Deficiency and the Onset of Alzheimer’s Disease
Lithium Deficiency and the Onset of Alzheimer’s Disease
PRJNA1150257 | ENA
GenomicsLithium Deficiency and the Onset of Alzheimer’s Disease [3xTG_LiO]
Lithium Deficiency and the Onset of Alzheimer’s Disease [3xTG_LiO]
PRJNA1256375 | ENA
TranscriptomicsGene expression profiling of lithium stimulated human mesenchymal stem cells
Wnt signaling in essential for osteoblast differentiation and is activated by lithium via inhibition of glycogen synthase kinase 3beta. Although lithium has been shown to enhance osteoblast differentiation in mice models and accelerate bone repair, its effect in humans is not clear. Therefore, we pe...
ORGANISM(S): Homo sapiens 
2013-02-02 | E-GEOD-34747 | biostudies-arrayexpress
TranscriptomicsLithium Deficiency and the Onset of Alzheimer’s Disease
The non-genetic causes of Alzheimer’s disease (AD) are poorly understood1-4. Here, we show that endogenous lithium (Li) is a dynamically regulated metal in the brain. Li uptake is the most significantly impaired of all metals analyzed in aged individuals with mild cognitive impairment (MCI) and AD, ...
ORGANISM(S): Mus musculus 
2025-06-09 | GSE272344 | GEO
TranscriptomicsLithium Deficiency and the Onset of Alzheimer’s Disease
The earliest molecular changes in Alzheimer’s disease (AD) are poorly understood. Here we show that endogenous lithium (Li) is dynamically regulated in the brain and contributes to cognitive preservation during aging. We demonstrate that cortical uptake of Li is the most significantly impaired of al...
ORGANISM(S): Mus musculus 
2025-06-12 | GSE275326 | GEO
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