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TranscriptomicsTranscription profiling of hippocampal neuronal cell line HT-22 after 7 days of 3mM Lithium treatment
Effect of 3 mM lithium on gene's expression in mouse hippocampal neuronal cell line HT-22 after 7 days of treatment
ORGANISM(S): Mus musculus 
2006-02-01 | E-MEXP-521 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of galactose-grown S. cerevisiae cells exposed to lithium chloride
Wild type strain CEN.PK113-7D was grown in an aerobic batch cultivation with a start concentration of 20 g/L galactose. During exponential growth at a biomass concentration of 3 g dry weight/L LiCl was added to a concentration of 10 mM. Just before addition of LiCl (time 0) and 20, 40, 60 and 140 mi...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-07 | E-GEOD-461 | biostudies-arrayexpress
TranscriptomicsLithium promotes longevity via GSK-3 and NRF-2 and is additive to other anti-aging interventions
The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that lithium extends lifespan in female and male Drosophi...
ORGANISM(S): Drosophila melanogaster 
2016-04-07 | E-MTAB-3809 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics of Daphnia magna exposed to a lithium cobalt oxide nanomaterial
Not available
ORGANISM(S): Daphnia magna 
ST001807 | MetabolomicsWorkbench
TranscriptomicsHyper-excitability of Neurons generated from Patients with Bipolar Disorder
Bipolar Disorder (BD) is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression and, without treatment, 15% of patients commit suicide1. Hence, among all diseases, BD has been ranked by the WHO as a top disorder of morbidity and lost productivity2....
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-58933 | biostudies-arrayexpress
ProteomicsSignaling Mechanisms in Initiation of Lithium-Induced Nephrogenic Diabetes Insipidus
Lithium treatment is commonly used to treat bipolar disorder. However, this treatment disrupts kidney fuctionality. We used microdissected cortical collecting ducts to study proteomics and ultimately discover what changes occur in protein expression after 72-hr lithium treatment.
ORGANISM(S): Rattus norvegicus (Rat) 
2019-07-01 | PXD010118 | Pride
Kidney Lithium Cortical collecting duct Proteome 
TranscriptomicsEffect of Lithium on Abeta utilising microarray analyses
Our previous work in a Drosophila model of Alzheimer's disease (AD) has shown that we can intervene into the pathways to slow or prevent AD progression. Lithium was able to rescue toxicity in the Drosophila AD model which corresponded with a reduction in Abeta levels. Furthermore, we have demonstra...
ORGANISM(S): Drosophila melanogaster 
2017-01-26 | E-MTAB-4611 | biostudies-arrayexpress
ProteomicsProteomic Profiling of the Hippocampus in Lithium-Deficient 3xTg-AD Mice
This proteomics experiment aimed to identify proteins whose abundance is altered by lithium deficiency in the context of Alzheimer's disease pathology in mice. Female homozygous 3xTg-AD mice were continuously fed either a lithium-deficient or a control diet from 6 to 15 months of age. At the end of ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD063039 | Pride
Hippocampus Alzheimer's disease Lithium Lithium deficiency 
TranscriptomicsGene expression profiling of lithium stimulated human mesenchymal stem cells
Wnt signaling in essential for osteoblast differentiation and is activated by lithium via inhibition of glycogen synthase kinase 3beta. Although lithium has been shown to enhance osteoblast differentiation in mice models and accelerate bone repair, its effect in humans is not clear. Therefore, we pe...
ORGANISM(S): Homo sapiens 
2013-02-02 | E-GEOD-34747 | biostudies-arrayexpress
TranscriptomicsRNA-seq of rat NSCs stimulated with lithium and/or photon radiation.
Investigation of lithium effects in rat neural stem cells exposed to irradiation to mimic cranial radiotherapy in children. We investigated whether lithium is involved in halting or even preventing gene expression regulation in the model system.
ORGANISM(S): Rattus norvegicus 
2019-10-01 | E-MTAB-7238 | biostudies-arrayexpress
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