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Tetracycline-treated Litomosoides sigmodontis vs. untreated control Litomosoides sigmodontis
The filarial nematodes Brugia malayi, Wuchereria bancrofti and Onchocerca volvulus cause elephantiasis, dermatitis and blindness, resulting in severe morbidity in developing countries. 1.3 billion people are at risk of infection. Targeting the essential Wolbachia endobacteria of filarial nematodes w...
ORGANISM(S): Litomosoides sigmodontis 
Filarial nematodes (superfamily Filarioidea) are responsible for an annual global health burden of approximately 6.3 million disability-adjusted life-years, which represents the greatest single component of morbidity attributable to helminths affecting humans. No vaccine exists for the major filaria...
ORGANISM(S): Litomosoides sigmodontis (Filarial nematode worm) 
2014-07-22 | PXD000756 | Pride
Litomosoides sigmodontis overview
Exosomes secreted by a nematode parasite transfer small RNAs to mammalian cells and regulate genes of the innate immune system [Litomosoides sigmodontis]
In mammalian systems, extracellular small RNAs can operate in a paracrine manner to communicate information between cells, relying on transport within vesicles. “Foreign” small RNAs derived from bacteria, plants and parasites have also been detected in mammalian body fluids, sparking interest in whe...
ORGANISM(S): Litomosoides sigmodontis 
Litomosoides sigmodontis
454 Sequencing of Litomosoides sigmodontis transcriptome from 3 lifestages
Wolbachia endosymbiont of Litomosoides sigmodontis overview
Litomosoides sigmodontis genome assembly, nxLitSigm11
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