Tetracycline-treated Litomosoides sigmodontis vs. untreated control Litomosoides sigmodontis

ABSTRACT: The filarial nematodes Brugia malayi, Wuchereria bancrofti and Onchocerca volvulus cause elephantiasis, dermatitis and blindness, resulting in severe morbidity in developing countries. 1.3 billion people are at risk of infection. Targeting the essential Wolbachia endobacteria of filarial nematodes with doxycycline has proven to be an effective therapy, resulting in a block in embryogenesis and worm development, and macrofilaricidal effects. However, doxycycline is contraindicated for a large portion of the at-risk population. To identify new targets for anti-wolbachial therapy, understanding the molecular basis of the Wolbachia-filaria symbiosis is required. We performed cross-species hybridization by using the Brugia malayi microarray to identify differentially expressed genes in the rode

ORGANISM(S): Litomosoides sigmodontis

SUBMITTER: Uta Strübing 

PROVIDER: E-GEOD-20976 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress