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TranscriptomicsA cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
Dendritic cells (DC) serve a key function in host defense, linking innate detection of microbes to the activation of pathogen-specific adaptive immune responses. Whether there is cell-intrinsic recognition of HIV-1 by host innate pattern-recognition receptors and subsequent coupling to antiviral T c...
ORGANISM(S): Homo sapiens 
2010-09-09 | E-GEOD-22589 | biostudies-arrayexpress
TranscriptomicsExpression data from GPR15+CD4+ and GPR15-CD4+ T cells in LILP
GPR15 is an orphan G-protein coupled receptor and its expression is abundant among T cells in the large intestine lamina propria. We used microarrays to examine charateristics of GPR15- vs GPR15+ CD4+ T cells in LILP and identified distinct classes of up-regulated genes in GPR15+ CD4+ T cells. We ha...
ORGANISM(S): Mus musculus 
2013-05-09 | E-GEOD-45773 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of RNAs bound by DDX5 and RORgt in cultured T helper 17 cell [RIP-seq]
Purpose: The goals of this study are to compare RNAs bound by DDX5 and RORgt in cultured T helper 17 cell in wildtype background. Methods: Th17 mRNA profiles of 48hrs in vitro cultured T helper 17 cells from wild-type mice were generated by deep sequencing, using Illumina HighSeq. The sequence read...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-70109 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type, DDX5 knockout, RORc knockout, RmrpG262T knockin T helper 17 cell Transcriptomes [RNA-seq]
Purpose: The goals of this study are to compare in vitro polarized T helper 17 cell transcriptome profiling (RNA-seq) in different genetic background. Methods: Th17 mRNA profiles of 96hrs in vitro cultured T helper 17 cells from wild-type and mutant mice were generated by deep sequencing, using Ill...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-70108 | biostudies-arrayexpress
TranscriptomicsDigoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity
CD4+ T helper lymphocytes that express interleukin-17 (Th17 cells) have critical roles in mouse models of autoimmunity, and there is mounting evidence that they also influence inflammatory processes in humans. Genome-wide association studies in humans have linked genes involved in Th17 cell differe...
ORGANISM(S): Mus musculus 
2011-03-28 | E-GEOD-27241 | biostudies-arrayexpress
TranscriptomicsGenes regulated by T cell and B cell derived TNF in naive lymph nodes
We present a RNA microarray analysis of RNA`s extracted from naive mesenterial lymph nodes of mice with specific inactivation of tumor necrosis factor only in B cells (B-TNf mice) or in T- and B-cells (TB-TNF mice). Several genes are cooperatively regulated by T cell derived and B cell derived TNF ...
ORGANISM(S): Mus musculus 
2010-12-07 | E-GEOD-8610 | biostudies-arrayexpress
GenomicsA validated regulatory network for Th17 cell specification
Th17 cells have critical roles in mucosal defense and are major contributors to inflammatory disease. Their differentiation requires the nuclear hormone receptor RORγt working with multiple other essential transcription factors (TFs). We have used an iterative systems approach, combining genome-wide...
ORGANISM(S): Mus musculus 
2012-09-20 | E-GEOD-40918 | biostudies-arrayexpress
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