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ProteomicsDiscovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation
PKMYT1 has recently emerged as a compelling therapeutic target for precision cancer therapy due to its synthetic lethality with oncogenic alterations such as CCNE1 amplification and mutations in FBXW7 and PPP2R1A. Current small molecule PKMYT1 inhibitors face limitations, such as insufficient molecu...
ORGANISM(S): Homo sapiens (Human) 
2025-09-28 | PXD062889 | Pride
Protac Pkmyt1 Synthetic lethality Ai-generation 
UnknownAI-MARRVEL - A Knowledge-Driven AI System for Diagnosing Mendelian Disorders.
Not available
S-EPMC11221788 | biostudies-literature
MetabolomicsIdentification of amniotic fluid metabolomic and placental transcriptomic changes associated with abnormal development of cloned pig fetuses
Piglets cloned by somatic cell nuclear transfer (SCNT) show a high incidence of malformations and a high death rate during the perinatal period. To investigate the underlying mechanisms for abnormal development of cloned pig fetuses, we compared body weight, amniotic fluid (AF) metabolome, and place...
2020-01-08 | MTBLS666 | MetaboLights
ProteomicsMassNet: billion-scale AI-ready mass spectral corpus empowering scalable deep learning in proteomics
Breakthroughs in artificial intelligence (AI) for natural language processing and computer vision have been largely driven by high-quality, large-scale datasets such as OpenWebText and ImageNet. Inspired by this, we present MassNet, a foundational resource for proteomics designed to accelerate deep ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Toxoplasma gondii Glycine max Mus musculus (Mouse) Capsicum annuum Acinetobacter baumannii Sus scrofa domesticus (domestic pig) Rhodopseudomonas palustris Homo sapiens (Human) Zea mays (Maize) Streptomyces coelicolor Callithrix jacchus Rattus norvegicus (Rat) Bacillus subtilis Legionella pneumophila Arabidopsis thaliana (Mouse-ear cress) Trypanosoma brucei Staphylococcus epidermidis Gallus gallus (Chicken) Drosophila melanogaster (Fruit fly) Oryza sativa (Rice) Caenorhabditis elegans Bacillus cereus Chlamydomonas reinhardtii Bos taurus (Bovine) Moorella thermoacetica Zymomonas mobilis Oryctolagus cuniculus (Rabbit) Pseudomonas aeruginosa Coffea arabica (Arabian coffee) Canis familiaris (Dog) (Canis lupus familiaris) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) Staphylococcus aureus Equus caballus (Horse) 
2026-10-20 | PXD071590 | Pride
UnknownProspective Multi-Site Validation of AI to Detect Tuberculosis and Chest X-Ray Abnormalities.
Not available
S-EPMC11737584 | biostudies-literature
UnknownAI and machine learning in resuscitation: Ongoing research, new concepts, and key challenges.
Not available
S-EPMC10400904 | biostudies-literature
Unknown"Liu-Liang-Chung" syndrome with multiple congenital anomalies and the distinctive craniofacial features caused by dominant ZEB2 gene gain mutation.
Not available
S-EPMC10512491 | biostudies-literature
MetabolomicsRegulatory actors and alternative routes for Arabidopsis seed germination are revealed using a pathway‐based analysis of transcriptomic datasets
Regulation of seed germination by dormancy relies on a complex network of transcriptional and post‐transcriptional modifications during seed imbibition that controls seed adaptive responses to environmental cues. High‐throughput technologies have brought significant progress in the understanding of ...
2019-05-21 | MTBLS662 | MetaboLights
UnknownA scoping review and evidence gap analysis of clinical AI fairness.
Not available
S-EPMC12167363 | biostudies-literature
UnknownFrom Trust in Automation to Trust in AI in Healthcare: A 30-Year Longitudinal Review and an Interdisciplinary Framework.
Not available
S-EPMC12562135 | biostudies-literature
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