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GenomicsCellular reprogramming by the conjoint action of ERalpha, FOXA1 and GATA3 to a ligand-inducible growth state
Despite the role of the estrogen receptor alpha (ERalpha) pathway as a key growth driver for breast cells, the phenotypic consequence of exogenous introduction of ERalpha into ERalpha-negative cells paradoxically has been growth inhibition. We map the binding profiles of ERalpha and its interacting ...
ORGANISM(S): Homo sapiens 
2011-09-05 | E-GEOD-29073 | biostudies-arrayexpress
TranscriptomicsCellular reprogramming by the conjoint action of ERalpha, FOXA1, and GATA3 to a ligand inducible growth state
Despite the role of the estrogen receptor alpha (ERalpha) pathway as a key growth driver for breast cells, the phenotypic consequence of exogenous introduction of ERalpha into ERalpha-negative cells paradoxically has been growth inhibition. We map the binding profiles of ERalpha and its interacting ...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-30574 | biostudies-arrayexpress
UnknownEffects of the gut microbiota on placental angiogenesis and intrauterine growth in gnotobiotic mice.
Not available
S-EPMC12318179 | biostudies-literature
GenomicsIntegrative model of genomic factors for determining binding site selection by estrogen receptor alpha in MCF-7 cancer cells
Using the estrogen receptor alpha (ERalpha) as a model ligand inducible transcription factor, we sought to explicitly define parameters that determine transcription factor binding site selection on a genomic scale in an inducible system that minimizes confounding chromatin effects by the transcripti...
ORGANISM(S): Homo sapiens 
2011-01-04 | E-GEOD-23701 | biostudies-arrayexpress
UnknownDifferential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis.
Not available
S-EPMC8282756 | biostudies-literature
MetabolomicsMetabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes
Hypoxic-Ischemic Encephalopathy (HIE) is one of the most relevant contributors to neurological disability in term infants. We hypothesized that clinical outcomes of newborns with (HIE) can be associated with changes at plasma metabolic level enabling the detection of brain injury. Plasma samples of ...
2021-11-09 | MTBLS1041 | MetaboLights
GenomicsIntegrative model of genomic factors for determining binding site selection by estrogen receptor alpha in MCF-7 cancer cells
Using the estrogen receptor alpha (ERalpha) as a model ligand inducible transcription factor, we sought to explicitly define parameters that determine transcription factor binding site selection on a genomic scale in an inducible system that minimizes confounding chromatin effects by the transcripti...
ORGANISM(S): Homo sapiens 
2011-01-25 | E-GEOD-26831 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary osteoblasts treated with estradiol or the pure antagonist ICI 182,780a potent inhibitor of estrogen receptor signaling
Transcriptional profiling of estrogen regulated genes in human primary osteoblasts. The cells were either treated with estradiol (1 nM) or the pure antagonist ICI 182,780 (Faslodex), which acts as a potent inhibitor of estrogen receptor signaling.
ORGANISM(S): Homo sapiens 
2007-08-01 | E-MEXP-1053 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer tumor samples from Uppsala and Singapore cohorts
Histological grading of breast cancer defines morphological subtypes informative of metastatic potential, although not without considerable inter-observer disagreement and clinical heterogeneity particularly among the moderately differentiated grade II (G2) tumors. We posited that a gene expression ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-4922 | biostudies-arrayexpress
GenomicsGenome-wide TNFM-NM-1-induced p65 binding before and after telomerase inhibition in HeLa cells
Chromatin immunoprecipitation sequencing (ChIP-seq) was performed to analyze the effect of telomerase inhibition on TNFM-NM-1-induced genome-wide p65 binding in HeLa cells. By obtaining over 40 million uniquely mappable reads per sample from ChIP-seq, maps for TNFM-NM-1-induced p65 binding in absenc...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-41100 | biostudies-arrayexpress
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