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MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
TranscriptomicsSel1L is Indispensable for Mammalian ERAD, ER Homeostasis and Survival
Sel1L is an adaptor protein for the E3 ligase Hrd1 involved in endoplasmic reticulum-associated degradation (ERAD). Its physiological importance in mammalian ERAD, however, remains to be established. Here, using the inducible Sel1L knockout mouse and cell models, we provide the first in vivo evidenc...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52929 | biostudies-arrayexpress
UnknownE-syt1 Re-arranges STIM1 Clusters to Stabilize Ring-shaped ER-PM Contact Sites and Accelerate Ca<sup>2+</sup> Store Replenishment.
Not available
S-EPMC6408583 | biostudies-literature
TranscriptomicsMolecular signaling distinguishes early from late recurrences in ER positive breast cancer
Unlike many other cancers, estrogen receptor-alpha (ER+) breast cancers are associated with cumulative risks of recurrence and death that persist for decades. We show that molecular differences between breast cancers that recur at distant sites early (² 3 years) or late (³ 5 years) support a robust ...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-46222 | biostudies-arrayexpress
ProteomicsA proteomic study on the membrane protein fraction of T cells confirms high substrate selectivity for the ER translocation inhibitor cyclotriazadisulfonamide
Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of type I integral membrane protein human CD4 (huCD4) across the ER in a signal peptide (SP)-dependent way. Previously, sortilin was identified as a secondary substrate for CADA but showed reduced CADA sensitivity as compare...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD027712 | Pride
Cd4  cyclotriazadisulfonamide (cada)  er co-translational translocation  signal peptide  silac 
UnknownCharacterization of patient-derived tumor xenografts (PDXs) as models for estrogen receptor positive (ER+HER2- and ER+HER2+) breast cancers.
Not available
S-EPMC5094906 | biostudies-literature
MetabolomicsSerum metabolomic profiles identify ER-positive early breast cancer patients at increased risk of disease recurrence in a multicentre population

PURPOSE: Detecting signals of micrometastatic disease in early breast cancer (EBC) patients could improve risk stratification and allow better tailoring of adjuvant therapies. We have previously shown that postoperative serum metabolomic profiles are predictive of relapse in a si...

2017-03-02 | MTBLS424 | MetaboLights
TranscriptomicsAdipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization
The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereb...
ORGANISM(S): Mus musculus 
2013-11-21 | E-GEOD-36031 | biostudies-arrayexpress
UnknownAgr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis.
Not available
S-EPMC9805753 | biostudies-literature
UnknownReticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules.
Not available
S-EPMC6742417 | biostudies-literature
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