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TranscriptomicsReactivity of commercial antibodies targeting human histone H2B N-terminal tail on the Intel array platform
The aim of the study was to test the Intel array platform and map the H2B epitopes bound by commercial antibody reagents. We also tested the ability of SET7 PKMT to methylate Intel array peptides. We diluted antibody reagents 1:1000 and incubated dilutions on the silicon-based Intel array platorm. ...
ORGANISM(S): Oryctolagus cuniculus 
2011-12-02 | E-GEOD-34034 | biostudies-arrayexpress
ProteomicsEndogenous Sulfane Sulfur Mediates the Oxidative Stress Response Process in Pseudomonas aeruginosa
Sulfane sulfur species are increasingly recognized as integral cellular components involved in sig-naling pathways and cytoprotection against oxidative stress in mammals. While their production in bacteria has been extensively studied, their functional role in bacterial oxidative stress defense re-m...
ORGANISM(S): Pseudomonas Aeruginosa 
2026-05-09 | PXD078215 |
ProteomicsFusobacterium nucleatum Promotes PD-L1 Expression in Macrophages by Inducing Exosomal lncRNA MANCR from Colorectal Cancer Cells
This mass spectrometry dataset was generated from RNA pull-down assays to identify proteins interacting with lncRNA MANCR in colorectal cancer cells (HCT116) and macrophages (THP-1)
ORGANISM(S): Homo Sapiens 
2026-01-04 | PXD072638 |
ProteomicsLysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals
We report herein a set of activity-based probes (ABPs; P3-P7) based on various lysine-reactive covalent warheads capable of global profiling of ligandable lysine within BRDs in live cells and animals. Chemoproteomic experiments with P7 by utilizing 2-ethynylbenzaldehyde (EBA) identified 18 endogenou...
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-04-10 | PXD058513 |
ProteomicsTransketolase promotes MAFLD by limiting inosine-induced mitochondrial activity (Proteomics)
Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and proteomic analyses, we identified high expression of hepatic transketolase (TKT), a metabolic enzyme of the pentose phosphate pathway, in human and mouse M...
ORGANISM(S): Homo Sapiens 
2024-02-26 | PXD050130 |
ProteomicsA Recombinant Vaccine Targeting Receptor-binding Domain of SARS-CoV-2 Spike Protein Induces Protective Immunity in Mice and Non-human Primates
The novel Coronavirus SARS-CoV-2 causes a respiratory illness called COVID-19 leading to a pandemic. An effective preventive vaccine against this virus is urgently needed.
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2020-07-30 | PXD020653 |
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