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Top-down proteomics of human serum is hindered by extreme dynamic range and cumbersome prefractionation. Here we establish a fully solution-based protein precipitation–solid-phase extraction (PP–SPE) workflow for deep, low-molecular-weight-biased proteoform profiling. Using systematically optimized ...
ORGANISM(S): Homo Sapiens 
Sepsis is often a cause of mortality in patients admitted to the intensive care unit. Notably, the heart is the organ most susceptible to the impact of sepsis.Mice injected intraperitoneally with LPS solution (20 mg/kg) were designated as the sepsis experimental group, while those injected intraperi...
ORGANISM(S): Mus Musculus 
2024-12-24 | PXD059227 |
Sepsis is often a cause of mortality in patients admitted to the intensive care unit. Notably, the heart is the organ most susceptible to the impact of sepsis.Mice injected intraperitoneally with LPS solution (20 mg/kg) were designated as the sepsis experimental group, while those injected intraperi...
ORGANISM(S): Mus Musculus 
2025-01-07 | PXD059523 |
Copper (Cu) performs essential structural and functional roles in all aerobic organisms, but identifying natural cuproproteins through traditional affinity methods is hindered by the variety of copper ligand combinations and binding locations in proteins. Here, using ATOX1 as a bait, fused with the ...
ORGANISM(S): Homo Sapiens 
Copper (Cu) performs essential structural and functional roles in all aerobic organisms, but identifying natural cuproproteins through traditional affinity methods is hindered by the variety of copper ligand combinations and binding locations in proteins. Here, using ATOX1 as a bait, fused with the ...
ORGANISM(S): Homo Sapiens 
The role of GATD3A (glutamine amidotransferase-like class 1 domain-containing 3A) in regulating functions of fibroblast-like synoviocytes was assessed by lentivirus infection and label-free proteomics assay.
ORGANISM(S): Homo Sapiens 
To explore the role of post-translational modification on UVRAG, we used tandem mass spectrometry (MS/MS) to analyze the UVRAG from cells.
ORGANISM(S): Homo Sapiens 
2022-06-14 | PXD034521 |
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