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UnknownGenome-Wide Mining of the Tandem Duplicated Type III Polyketide Synthases and Their Expression, Structure Analysis of Senna tora.
Senna tora is one of the homologous crops used as a medicinal food containing an abundance of anthraquinones. Type III polyketide synthases (PKSs) are key enzymes that catalyze polyketide formation; in particular, the chalcone synthase-like (CHS-L) genes are involved in anthraquinone producti...
S-EPMC10003783 | biostudies-literature
MetabolomicsNMR-based metabonomics and correlative analysis reveals potential bomarkers associated with chronic atrophic gastritis
Chronic atrophic gastritis (CAG) is one of the most important pre-cancerous states with a high prevalence. Exploring of the underlying mechanism and potential biomarkers is of significant importance for CAG. In the present work, 1H NMR-based metabonomics with correlative analysis was performed to an...
2016-08-31 | MTBLS340 | MetaboLights
UnknownIdentification of simple arylfluorosulfates as potent agents against resistant bacteria.
Sulfur fluoride exchange (SuFEx), a next generation of click chemistry, opens an avenue for drug discovery. We report here the discovery and structure-activity relationship studies of a series of arylfluorosulfates, synthesized via SuFEx, as antibacterial agents. Arylfluorosulfates 3, 81, and 101 sh...
S-EPMC8285976 | biostudies-literature
ProteomicsAdaptiven mechanism of antibiotic resistant Staphylococus aureus to host environment
Antibiotic-resistant bacteria can escape from the killing of host immune and settle in the host to form persistent infections. In this study, we investigated the environmental adaptation mechanism of resistant Staphyloccus aureus (S. aureus) to host environment by Data-independent acquisition based ...
ORGANISM(S): Staphylococcus aureus 
2022-05-31 | PXD029584 | Pride
Host environment Ciprofloxacin-resistant Proteomics Staphylococcus aureus 
Proteomicsproteomic analysis of the formalin-fixed paraffin embedded (FFPE) renal tissue between steroid-sensitive and steroid-resistant (SR) children FSGS patients
In children, focal segmental glomerulosclerosis (FSGS) is the main cause of steroid resistant nephroticsyndrome (SRNS). To identify specific candidates and the mechanism of steroid resistance, we examined the formalin-fixed paraffin embedded (FFPE) renal tissue protein profiles via liquid chromatogr...
ORGANISM(S): Homo sapiens (Human) 
2022-11-19 | PXD036164 | Pride
Kidney tissue Human Lc-ms/ms 
UnknownKPT330 improves Cas9 precision genome- and base-editing by selectively regulating mRNA nuclear export.
CRISPR-based genome engineering tools are associated with off-target effects that constitutively active Cas9 protein may instigate. Previous studies have revealed the feasibility of modulating Cas9-based genome- and base-editing tools using protein or small-molecule CRISPR inhibitors. Here we screen...
S-EPMC8931069 | biostudies-literature
ProteomicsNucleolar beacon for monitoring nucleolar morphology and proteomics in living cells
A novel approach combined nucleolar beacon with proximity labeling to obtain the nucleolar proteome. These techniques offer effective tools for investigating nucleolar functions in living cells and present a potential application method for drug delivery.
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD059125 | Pride
Nucleolar proteomics nucleolar beacon proximity labeling 
TranscriptomicsMIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes
The piRNA machinery is known for its role in mediating epigenetic silencing of transposons. Recent studies suggest that this function also involves piRNA-guided cleavage of transposon-derived transcripts. As many piRNAs also appear to have the capacity to target diverse mRNAs, this raises the intrig...
ORGANISM(S): Mus musculus 
2015-04-09 | E-GEOD-67683 | biostudies-arrayexpress
ProteomicsTransfer of the high-quality sugar metabolic model of Aspergillus niger is reliable within the same fungal phylum, but limited for fungi of other phyla
Validation of metabolic models, extrapolated from the reference sugar catabolism genetic network of Aspergillus niger by using an orthology-based approach, of evolutionarily diverse fungi.
ORGANISM(S): Trichoderma Reesei (ncbitaxon:51453) Penicillium Subrubescens (ncbitaxon:1316194) Aspergillus Niger (ncbitaxon:5061) Phanerochaete Chrysosporium Rp-78 (ncbitaxon:273507) Aspergillus Nidulans (ncbitaxon:162425) 
MSV000090441 | MassIVE
UnknownSpecific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.
Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although many assays are available, highly robust and reliable methods are always desired. By combining...
S-EPMC10103678 | biostudies-literature
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